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Titolo:
HYPOECHOIC PLAQUE AT US OF THE CAROTID-ARTERY - AN INDEPENDENT RISK FACTOR FOR INCIDENT STROKE IN ADULTS AGED 65 YEARS OR OLDER
Autore:
POLAK JF; SHEMANSKI L; OLEARY DH; LEFKOWITZ D; PRICE TR; SAVAGE PJ; BRANT WE; REID C;
Indirizzi:
BRIGHAM & WOMENS HOSP,DEPT RADIOL,75 FRANCIS ST BOSTON MA 02115 UNIV WASHINGTON,CHS COORDINATING CTR SEATTLE WA 98195 TUFTS UNIV,NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 02111 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT NEUROL WINSTON SALEM NC 27103 UNIV MARYLAND BALTIMORE CTY,DEPT NEUROL BALTIMORE MD 21228 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,EPIDEMIOL & BIOMETRY PROGRAM BETHESDA MD 20892 UNIV CALIF DAVIS,MED CTR,DEPT RADIOL DAVIS CA 00000 UNIV CALIF IRVINE,DIV CARDIOL IRVINE CA 92717
Titolo Testata:
Radiology
fascicolo: 3, volume: 208, anno: 1998,
pagine: 649 - 654
SICI:
0033-8419(1998)208:3<649:HPAUOT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR HEALTH; MORPHOLOGY; ATHEROSCLEROSIS; STENOSES; DISEASE; ENDARTERECTOMY; HEMORRHAGE; SYMPTOMS;
Keywords:
CAROTID ARTERIES; CAROTID ARTERIES, DISEASES; CAROTID ARTERIES, STENOSIS OR OBSTRUCTION; CAROTID ARTERIES, US;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Polak et al., "HYPOECHOIC PLAQUE AT US OF THE CAROTID-ARTERY - AN INDEPENDENT RISK FACTOR FOR INCIDENT STROKE IN ADULTS AGED 65 YEARS OR OLDER", Radiology, 208(3), 1998, pp. 649-654

Abstract

PURPOSE: To investigate the association between incident (first) stroke and the echogenicity of internal carotid arterial plaque at ultrasonography (US). MATERIALS AND METHODS: A cohort of 4,886 individuals who, at baseline, were 65 years of age or older and without symptoms of cerebrovascular disease was followed up for an average of 3.3 years. Baseline clinical findings were from color Doppler and duplex US studies of the carotid arteries and a record of traditional risk age, sex, presence of diabetes mellitus, pack-years of cigarette smoking, presence of hypertension, elevated systolic and diastolic blood pressures, elevated low-density lipoprotein cholesterol level. RESULTS: incident strokes, excluding hemorrhagic strokes and strokes of cardiac origin, were seen in 104 individuals (2.1%) at risk. Age- and sex-adjusted odds ratios for incident stroke were significant for hypoechoic plaque (odds ratio, 2.53; 95% CI, 1.42, 4.53). After controlling for risk factorsin a Cox proportional hazards model, the relative risk (RR) of incident stroke was 1.72 (P = .015) for hypoechoic plaque and 2.32 (P = .004) for internal carotid arterial narrowing of at least 50%. In addition, hypoechoic plaque (RR, 2.78; CI, 1.36, 5.69) and 50%-100% stenosis (RR, 3.08; CI, 1.28,,7.41)were associated with ipsilateral, nonfatal stroke. CONCLUSION: In asymptomatic adults aged 65 years or older, the risk of incident stroke was associated with two US features: hypoechoicinternal carotid arterial plaque and an estimated internal carotid arterial stenosis of 50%-100%.

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Documento generato il 25/11/20 alle ore 15:38:27