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Titolo:
DIETARY SULFATE REGULATES THE EXPRESSION OF THE RENAL BRUSH-BORDER NAS-I COTRANSPORTER NASI-1/
Autore:
MARKOVICH D; MURER H; BIBER J; SAKHAEE K; PAK C; LEVI M;
Indirizzi:
UNIV QUEENSLAND,DEPT PHYSIOL & PHARMACOL ST LUCIA QLD 4072 AUSTRALIA UNIV ZURICH IRCHEL,INST PHYSIOL ZURICH SWITZERLAND UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED DALLAS TX 00000 DEPT VET AFFAIRS MED CTR DALLAS TX 00000
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 9, volume: 9, anno: 1998,
pagine: 1568 - 1573
SICI:
1046-6673(1998)9:9<1568:DSRTEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INORGANIC SULFATE; THYROID-HORMONE; MESSENGER-RNA; PI TRANSPORT; RAT-KIDNEY; HOMEOSTASIS; ADAPTATION; INHIBITION; MEMBRANES; CLEARANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D. Markovich et al., "DIETARY SULFATE REGULATES THE EXPRESSION OF THE RENAL BRUSH-BORDER NAS-I COTRANSPORTER NASI-1/", Journal of the American Society of Nephrology, 9(9), 1998, pp. 1568-1573

Abstract

Dietary inorganic sulfate (Si) intake is an important factor in the regulation of renal proximal tubular sodium-dependent Si transport (Na/S-i cotransport). The purpose of the present study was to determine whether modulation of Na/S-i cotransport activity by dietary Si is mediated through regulation of the renal expression of the recently cloned NaSi-1 protein located in the apical brush border membrane (BBM) of the proximal tubule. It was found that rats fed a high Si diet had a marked increase in the renal excretion of Si and a concomitant decrease in BBM Na/Si cotransport activity when compared with rats on a control Si diet. The 43% decrease in BBM Na/S-i cotransport activity was associated with a 33% decrease in BBM NaSi-1 protein abundance, as determined by Western blotting, and a 2.7-fold decrease in cortical NaSi-1 mRNA abundance, as determined by Northern blotting. Furthermore, corticalmRNA from rats fed a high Si diet when injected into Xenopus laevis oocytes led to a 2.2-fold decrease in Na/Si cotransport activity compared with mRNA isolated from control Si diet rats. This study indicates that adaptation to a high Si diet is accompanied by a decrease in renal cortical NaSi-1 mRNA abundance, which results in reduced expression of the NaSi-1 protein at the level of the proximal tubular BBM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:05:44