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Titolo:
MEMORY IMPAIRMENTS ASSOCIATED WITH HIPPOCAMPAL VERSUS PARAHIPPOCAMPAL-GYRUS ATROPHY - AN MR VOLUMETRY STUDY IN ALZHEIMERS-DISEASE
Autore:
KOHLER S; BLACK SE; SINDEN M; SZEKELY C; KIDRON D; PARKER JL; FOSTER JK; MOSCOVITCH M; WINCOUR G; SZALAI JP; BRONSKILL MJ;
Indirizzi:
MCGILL UNIV,MONTREAL NEUROL INST,COGNIT NEUROSCI UNIT,3801 UNIV ST MONTREAL PQ H3A 2B4 CANADA UNIV TORONTO,ROTMAN RES INST,BAYCREST CTR GERIATR CARE TORONTO ON CANADA SUNNYBROOK HLTH SCI CTR,COGNIT NEUROL UNIT TORONTO ON M4N 3M5 CANADA UNIV TORONTO,DEPT MED TORONTO ON CANADA UNIV TORONTO,CLIN EPIDEMIOL & HLTH CARE RES PROGRAM,SUNNYBROOK UNIT TORONTO ON CANADA SUNNYBROOK HLTH SCI CTR,DEPT MED BIOPHYS TORONTO ON M4N 3M5 CANADA UNIV TORONTO,DEPT PSYCHOL TORONTO ON M5S 1A1 CANADA TRENT UNIV,DEPT PSYCHOL PETERBOROUGH ON K9J 7B8 CANADA
Titolo Testata:
Neuropsychologia
fascicolo: 9, volume: 36, anno: 1998,
pagine: 901 - 914
SICI:
0028-3932(1998)36:9<901:MIAWHV>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL TEMPORAL-LOBE; POSITRON EMISSION TOMOGRAPHY; EPISODIC MEMORY; FRONTAL-LOBE; PREFRONTAL CORTEX; FORMATION SIZE; VERBAL MEMORY; AMNESIA; DEMENTIA; MONKEYS;
Keywords:
ANTEROGRADE AMNESIA; HIPPOCAMPUS; MEDIAL TEMPORAL LOBES; HUMAN; EPISODIC MEMORY; MAGNETIC RESONANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
S. Kohler et al., "MEMORY IMPAIRMENTS ASSOCIATED WITH HIPPOCAMPAL VERSUS PARAHIPPOCAMPAL-GYRUS ATROPHY - AN MR VOLUMETRY STUDY IN ALZHEIMERS-DISEASE", Neuropsychologia, 36(9), 1998, pp. 901-914

Abstract

Delayed memory impairments and medial temporal-lobe atrophy are considered to be cardinal features of Alzheimer's disease (AD). The goal ofthe present magnetic resonance (MR) volumetry study was to investigate the relationship between both features. We determined MR-derived estimates of hippocampal and parahippocampal volume in a sample of 27 AD patients and in a group of 26 healthy control subjects (NCs) of comparable age and education. We examined the performance of the two groups on immediate and delayed recall trials of an auditory-verbal list-learning task (CVLT), a visual non-verbal memory task (Visual Reproductionof the WMS-R), and a screening procedure that provides an estimate ofoverall cognitive functioning (DRS). Volumes of the hippocampus and the parahippocampal gyrus were significantly smaller in AD patients than in NCs. AD patients were impaired in their overall level of cognitive functioning and showed memory deficits under immediate and delayed recall conditions. The association between medial temporal-lobe atrophyand cognitive impairments in AD was found to be highly specific: Hippocampal volume correlated positively with delayed but not immediate recall of the verbal-auditory list learning task. In contrast: parahippocampal gyrus volume, specifically in the right hemisphere, was positively related to delayed but not immediate recall of the non-verbal visual memory task. In NCs: there was a trend towards a negative association between hippocampal volumes and delayed verbal recall. Our results suggest that hippocampal and parahippocampal gyrus atrophy in AD are related to distinct aspects of the patients' memory impairments. Our findings have implications for current discussions regarding contributions of the hippocampus and the parahippocampal gyrus to memory in the intact human brain. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Documento generato il 11/07/20 alle ore 20:52:52