Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
OXYNTOMODULIN REDUCES HYDROMINERAL TRANSPORT THROUGH RAT SMALL-INTESTINE
Autore:
BEAUCLAIR F; ETO B; PANSU D; RODIER G; MOCHIZUKI T; MARTINEZ J; BATAILLE D; JARROUSSE C;
Indirizzi:
CHU ARNAUD DE VILLENEUVE,INSERM,U376,LAB ENDOCRINOL PEPTIDES & REGULAT GEN,371 RUE DOYEN GIRAUD F-34295 MONTPELLIER 5 FRANCE CHU ARNAUD DE VILLENEUVE,INSERM,U376,LAB ENDOCRINOL PEPTIDES & REGULAT GEN F-34295 MONTPELLIER 5 FRANCE CONSERVATOIRE NATL ARTS & METIERS,BIOL LAB F-75141 PARIS FRANCE HOP EDOUARD HERRIOT,EPHE,LAB PHYSIOL ECHANGES MINERAUX F-69437 LYON FRANCE UNIV SHIZUOKA,SCH PHARMACEUT SCI,BIOORGAN CHEM LAB SHIZUOKA 422 JAPAN FAC PHARM MONTPELLIER,LAB CHIM PEPTIDES F-34060 MONTPELLIER FRANCE
Titolo Testata:
Digestive diseases and sciences
fascicolo: 8, volume: 43, anno: 1998,
pagine: 1814 - 1823
SICI:
0163-2116(1998)43:8<1814:ORHTTR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; GUT; GLICENTIN; PEPTIDE; IMMUNOREACTIVITY; GLUCAGON; RELEASE; JEJUNUM; PLASMA; ILEUM;
Keywords:
OXYNTOMODULIN; GLICENTIN; DUODENUM; JEJUNUM; LIGATED LOOP; USSING CHAMBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
F. Beauclair et al., "OXYNTOMODULIN REDUCES HYDROMINERAL TRANSPORT THROUGH RAT SMALL-INTESTINE", Digestive diseases and sciences, 43(8), 1998, pp. 1814-1823

Abstract

Glicentin (GLIC) and oxyntomodulin (OXM) are released from the ileum and colon during digestion. Both hormones reduce fluid and proton secretion in the stomach. The luminal concentration of sodium and chlorideunderlying the nutrient absorption, the effect of OXM on electrolyte transport through the small intestine, was assessed in vivo using ligated loops and in vitro using Ussing chambers. In vivo, a zero transport stale, estimated by the net water, chloride, and sodium fluxes, was observed when an 80 mM NaCl normoosmolar solution (274 mosm) was administered intraluminally. Active secretion was observed with hyperosmotic challenge (474 mosm). The amplitude of this active secretion increased 2.5- to 3-fold when an electrogenic challenge (NaCl 40 mM) was substituted to the hyperosmotic one. OXM (800 fmol/ml plasma) did not modify the basal transport in the duodenum or in the jejunum (t = 45 min). When active secretion was induced by the hyperosmotic challenge, OXM (200 fmol/ml plasma) had no effect on duodenal or jejunal transport (t= 50 min). When active secretion was induced by an electrogenic challenge, OXM (300 fmol/ml plasma) preferentially reduced the hydromineraltransport in jejunum. In vitro, OXM also induced a reduction in the ion transport towards the jejunal lumen (EC50 = 20 pM), the amplitude of which depended upon the integrity of the tetrodotoxin-sensitive neurons. In conclusion, OXM was able to reduce the large secretion inducedin rat jejunum in vivo by an electrogenic gradient. In vitro, the antisecretory effect of OXM was partly mediated by the neurons present inthe intrajejunal wall.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:10:05