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Titolo:
CEPHALOSPORIN ANTIBIOTICS ACCELERATE GASTRIC-EMPTYING IN MICE
Autore:
KUO WH; WADWA KS; FERRIS CD;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,DIV GASTROENTEROL,725 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,DIV GASTROENTEROL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT MED BALTIMORE MD 21205
Titolo Testata:
Digestive diseases and sciences
fascicolo: 8, volume: 43, anno: 1998,
pagine: 1690 - 1694
SICI:
0163-2116(1998)43:8<1690:CAAGIM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETIC GASTROPARESIS; ORAL ERYTHROMYCIN; DOUBLE-BLIND; METOCLOPRAMIDE; MOTILITY; MELLITUS; BETHANECHOL; SOLIDS; DOGS;
Keywords:
CEPHALOSPORIN; GASTRIC EMPTYING; ERYTHROMYCIN; GASTROPARESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W.H. Kuo et al., "CEPHALOSPORIN ANTIBIOTICS ACCELERATE GASTRIC-EMPTYING IN MICE", Digestive diseases and sciences, 43(8), 1998, pp. 1690-1694

Abstract

Gastroparesis is a common debilitating complication in many diabetic patients. While several drugs are available for gastroparesis, many patients are not adequately treated. Many patients do not respond to available drugs or appear to develop tachyphylaxis after an initial response. New agents are needed. Erythromycin is a macrolide antibiotic that accelerates gastric emptying through interaction with motilin receptors, Many antibiotics, like erythromycin itself, have significant gastrointestinal side effects. We investigated the ability of cephalosporin antibiotics to alter gastric emptying in mice by employing phenol red spectrophotometry to monitor gastric emptying. Our results indicate that several cephalosporin antibiotics, particularly cefazolin, accelerate gastric emptying. In some cases these drugs appear more efficacious than either erythromycin or metoclopramide. At very high doses, many drugs, including erythromycin, appear to delay gastric emptying. We hypothesize that the gastrointestinal side effects of nausea and vomiting may result from delayed gastric emptying occurring at high doses while lower doses are prokinetic in the stomach.

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Documento generato il 20/10/20 alle ore 05:23:03