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Titolo:
RAPID SIMPLE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OFPAROXETINE IN HUMAN PLASMA
Autore:
SHIN JG; KIM KA; YOON YR; CHA IJ; KIM YH; SHIN SG;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL & MED,DIV CLIN PHARMACOL,RM SE408,MED DENT BLDG WASHINGTON DC 20007 PUSAN PAIK HOSP,CLIN PHARMACOL CTR PUSAN 614735 SOUTH KOREA INJE UNIV,COLL MED,PUSAN PAIK HOSP,DEPT PSYCHIAT PUSAN 614735 SOUTH KOREA SEOUL NATL UNIV,COLL MED,DEPT PHARMACOL SEOUL 110799 SOUTH KOREA INJE UNIV,COLL MED,DEPT PHARMACOL PUSAN 614735 SOUTH KOREA
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 2, volume: 713, anno: 1998,
pagine: 452 - 456
SICI:
0378-4347(1998)713:2<452:RSHLDO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPARTEINE OXIDATION POLYMORPHISM; SEROTONIN REUPTAKE INHIBITORS; HUMAN LIVER-MICROSOMES; CYTOCHROME-P4502D6; HYDROXYLATION; FLUVOXAMINE; METABOLISM;
Keywords:
PAROXETINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Shin et al., "RAPID SIMPLE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OFPAROXETINE IN HUMAN PLASMA", Journal of chromatography B. Biomedical sciences and applications, 713(2), 1998, pp. 452-456

Abstract

A rapid, simple method for the measurement of paroxetine in human plasma by reversed-phase high-performance liquid chromatography (HPLC) with fluorescence detection is described. This method includes only one-step extraction of paroxetine and dibucaine, an internal standard, with chloroform. Their recoveries were around 90%. The mobile phase, 10 mM phosphate buffer-acetonitrile (40:60, v/v) was eluted isocratically. Between- and within-day coefficients of variation were in the range of 1.9-9.4% and 2.3-13.3%, respectively. The detection limit was 0.2 ng/ml. The method we describe can be easily applied to the measurement of plasma paroxetine concentration for pharmacokinetic studies as well as for therapeutic drug monitoring in patients taking paroxetine. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:00:16