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Titolo:
PREPARATION OF [C-11] TRIAMCINOLONE ACETONIDE
Autore:
BERRIDGE MS; CASSIDY EH; BORDEAUX KG;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT RADIOL,2074 ABINGTON RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT CHEM CLEVELAND OH 44106 RHONE POULENC RORER,CENT RES,DEPT DRUG DISPOSIT COLLEGEVILLE PA 19426
Titolo Testata:
Applied radiation and isotopes
fascicolo: 1, volume: 45, anno: 1994,
pagine: 91 - 95
SICI:
0969-8043(1994)45:1<91:PO[TA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Berridge et al., "PREPARATION OF [C-11] TRIAMCINOLONE ACETONIDE", Applied radiation and isotopes, 45(1), 1994, pp. 91-95

Abstract

Triamcinolone acetonide is commercially available in a variety of formulations for local administration as an anti-inflammatory agent. In order to evaluate the effectiveness of various dosage methods and the kinetics of subsequent absorption and distribution, the acetonide was labeled with carbon-11 for use in PET studies. Labeled acetone was usedas a synthetic intermediate and reacted with triamcinolone to producethe acetonide. Chemical yields of 5-10% were obtained without added carrier, and yields of 15-25% were obtained by adding carrier acetone. Without added carrier, it was necessary to add triethyl orthoformate in order to achieve reasonable yields of acetonide. The time required for synthesis was 45 min.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:23:17