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Titolo:
SPECTRUM OF PROTON-INDUCED MUTAGENESIS OF THE ESCHERICHIA-COLI CRP GENE
Autore:
TAKIMOTO K; YAMAMOTO K; SAGARA T; ISHIZAKI K;
Indirizzi:
YAMAGUCHI UNIV,FAC AGR,DEPT BIOL CHEM,1677-1 YOSHIDA YAMAGUCHI 753 JAPAN KYOTO UNIV,CTR RADIAT ONCOL KYOTO 606 JAPAN TOHOKU UNIV,FAC SCI,INST BIOL SENDAI MIYAGI 980 JAPAN
Titolo Testata:
MUTATION RESEARCH
fascicolo: 1, volume: 314, anno: 1994,
pagine: 1 - 9
SICI:
0027-5107(1994)314:1<1:SOPMOT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-INDUCED MUTAGENESIS; IONIZING-RADIATION; BASE SUBSTITUTION; GAMMA-RAYS; G.C->T.A TRANSVERSIONS; MUTATIONAL SPECIFICITY; DEFICIENT MUTANTS; RECEPTOR PROTEIN; SEQUENCE CHANGES; STRANDED-DNA;
Keywords:
RADIATION; PROTONS; TRANSVERSION; DNA SEQUENCE CHANGE; ESCHERICHIA-COLI CRP GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K. Takimoto et al., "SPECTRUM OF PROTON-INDUCED MUTAGENESIS OF THE ESCHERICHIA-COLI CRP GENE", MUTATION RESEARCH, 314(1), 1994, pp. 1-9

Abstract

Mutation of the adenosine 3',5'-cyclic monophosphate receptor proteingene (crp) of Escherichia coli induced by protons, ionizing radiationof charged particles, was analyzed to determine the specificity of the mutational spectrum. The majority, 44 of 49 mutations detected, werebase substitutions, and three frameshifts and two gross structural changes were also found. Base substitutions included 35 transversions and nine transitions. G:C to T:A transversions were the dominant type ofbase substitution, followed by G:C to C:G and A:T to T:A transversions. Almost all transitions were eight G:C to A:T changes. The spectrum of proton mutagenesis was quite different from that of X-ray mutagenesis of the crp gene, in which G:C to A:T transitions dominated.

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Documento generato il 21/09/20 alle ore 03:05:41