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Titolo:
PROTECTIVE EFFECT OF PRALIDOXIME ON MUSCLE-FIBER NECROSIS INDUCED BY ORGANOPHOSPHATE COMPOUNDS
Autore:
CAVALIERE MJ; PUGA FR; CALORE EE; CALORE NMP; PELEGRINO JD; DAROSA AR; WEG R;
Indirizzi:
INST ADOLFO LUTZ REGISTRO,DIV PATOL,AV DR ARNALDO,351-7A BR-01246001 SAO PAULO BRAZIL INST BIOL SAO PAULO BRAZIL INST EMILIO RIBAS SAO PAULO BRAZIL UNIV SAO PAULO SAO PAULO BRAZIL
Titolo Testata:
Journal of toxicology. Clinical toxicology
fascicolo: 4, volume: 36, anno: 1998,
pagine: 295 - 300
SICI:
0731-3810(1998)36:4<295:PEOPOM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIMES; MYOPATHY; RAT; ACETYLCHOLINESTERASE; DIAPHRAGM; ANTIDOTES; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Cavaliere et al., "PROTECTIVE EFFECT OF PRALIDOXIME ON MUSCLE-FIBER NECROSIS INDUCED BY ORGANOPHOSPHATE COMPOUNDS", Journal of toxicology. Clinical toxicology, 36(4), 1998, pp. 295-300

Abstract

Objective: To determine the protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate acute intoxication in rats. Design: Adult male Wistar rats were given oral organophosphate compounds dissolved in glycerol formal: dichlorvos, isofenphos, metamidophos, and diazinon, Half of the animals also received pralidoxime mesylate (20 mg/kg, intraperitoneal). Control animals received only the solvent. Twenty-four hours after treatment, the diaphragm muscle was collected for histological counts of necrotic muscle fibers in transverse sections. Results: Metamidophos- and isofenphos-treated animals showed the highest percentage of necrotic muscle fibers: 1.66 +/- 1.112 and 1.34 +/- 0.320, respectively, Diazinon-treated animals had a lower percentage of necrotic fibers: 0.40 +/- 0.032 (p < 0.05) compared to the first 2 products, and dichlorvos-treated animals showed the smallest: 0.05 +/- 0.021 (p < 0.05) when compared to the other 3 products. Pralidoxime reduced necrotic fibers about 20 times in metamidophos-treated animals, 10 times in isofenphos-treated animals and 6 times in diazinon-treated animals. Pralidoxime administration did not increase plasma cholinesterase activity in any group, although symptoms were reduced, Conclusions: Grime reduced diaphragmatic muscle necrosis in experimentalorganophosphate intoxication, despite little effect on plasma cholinesterase. Since respiratory insufficiency is an important cause of mortality and morbidity in organophosphate intoxications, early oxime administration may be particularly beneficial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 23:24:28