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Titolo:
SALT APPETITE - INTERACTION OF FOREBRAIN ANGIOTENSINERGIC AND HINDBRAIN SEROTONERGIC MECHANISMS
Autore:
MENANI JV; COLOMBARI DSA; BELTZ TG; THUNHORST RL; JOHNSON AK;
Indirizzi:
UNIV IOWA,DEPT PSYCHOL,11 SEASHORE HALL E IOWA CITY IA 52242 UNIV IOWA,DEPT PSYCHOL IOWA CITY IA 52242 UNIV IOWA,DEPT PHARMACOL IOWA CITY IA 52242 UNIV IOWA,CTR CARDIOVASC IOWA CITY IA 52242 PAULISTA STATE UNIV,DEPT PHYSIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 801, anno: 1998,
pagine: 29 - 35
SICI:
0006-8993(1998)801:1-2<29:SA-IOF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL PARABRACHIAL NUCLEUS; SUBFORNICAL ORGAN; SODIUM APPETITE; AREA POSTREMA; EFFERENT CONNECTIONS; RENIN-ANGIOTENSIN; WATER-INTAKE; RAT; DRINKING; ORGANIZATION;
Keywords:
FOREBRAIN ANGIOTENSINERGIC MECHANISM; HINDBRAIN SEROTONERGIC MECHANISMS; LOSARTAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.V. Menani et al., "SALT APPETITE - INTERACTION OF FOREBRAIN ANGIOTENSINERGIC AND HINDBRAIN SEROTONERGIC MECHANISMS", Brain research, 801(1-2), 1998, pp. 29-35

Abstract

Methysergide injected bilaterally into the lateral parabrachial nucleus (LPBN) increases NaCl intake in several models of renin-dependent salt appetite. The present study investigated the role of angiotensin Type 1 (AT(1)) receptors in the subfornical organ (SFO) on this effect. The intake of 0.3 M NaCl and water was induced by combined administration of the diuretic, furosemide (FURO), and the angiotensin-converting enzyme inhibitor, captopril (CAP). Pretreatment of the SFO with an AT, receptor antagonist, losartan (1 mu g/200 nl), reduced water intakebut not 0.3 M NaCl intake induced by subcutaneous FURO + CAP. Methysergide (4 mu g/200 nl) injected bilaterally into the LPBN increased 0.3M NaC1 intake after FURO + CAP. Losartan injected into the SFO prevented the additional 0.3 M NaC1 intake caused by LPBN methysergide injections. These results indicate that AT, receptors located in the SFO may have a role in mediating an enhanced sodium intake produced by methysergide treatment. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:15:51