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Titolo:
SYNAPTIC SIGNALING IN AN ACTIVE CENTRAL NETWORK ONLY MODERATELY CHANGES PASSIVE MEMBRANE-PROPERTIES
Autore:
RAASTAD M; ENRIQUEZDENTON M; KIEHN O;
Indirizzi:
UNIV OSLO,DEPT NEUROPHYSIOL,INST BASIC MED SCI,BOX 1104 N-0317 OSLO NORWAY UNIV COPENHAGEN,PANUM INST,DEPT PHYSIOL,SECT NEUROPHYSIOL DK-2200 COPENHAGEN N DENMARK
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 17, volume: 95, anno: 1998,
pagine: 10251 - 10256
SICI:
0027-8424(1998)95:17<10251:SSIAAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; INDUCED LOCOMOTOR-ACTIVITY; VITRO NEONATAL RAT; IN-VITRO; FICTIVE LOCOMOTION; NEURONS; PATTERN; CELLS; CAT; INTERNEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Raastad et al., "SYNAPTIC SIGNALING IN AN ACTIVE CENTRAL NETWORK ONLY MODERATELY CHANGES PASSIVE MEMBRANE-PROPERTIES", Proceedings of the National Academy of Sciences of the United Statesof America, 95(17), 1998, pp. 10251-10256

Abstract

The membrane resistance of mammalian central neurons may be dramatically reduced by synaptic events during network activity, thereby changing their integration properties. We have used the isolated neonatal rat spinal cord to provide measurements of the effect of synaptic signaling on passive membrane properties during network activity. Synaptic signaling could take place during fictive locomotor activity with only modest (on average 35%) reduction of the input resistance (R-in) and of the cell's charging time constant (tau(in)). Individual synaptic signals, however, often introduced a peak conductance that was greater than the input conductance (G(in) = 1/R-in) without synaptic activity. The combination of moderate average synaptic conductance and large conductance of individual synaptic signals suggests that individual presynaptic neurons have large but short-lasting influence on the integration properties of postsynaptic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:29:59