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Titolo:
EVALUATION OF THE FILTER-PAPER BLOOD COLLECTION METHOD FOR DETECTING OG4C3 CIRCULATING ANTIGEN IN BANCROFTIAN FILARIASIS
Autore:
GYAPONG JO; OMANEBADU K; WEBBER RH;
Indirizzi:
MINIST HLTH,HLTH RES UNIT,POB 184 ACCRA GHANA UNIV LONDON LONDON SCH HYG & TROP MED,DEPT INFECT & TROP MED LONDON WC1E 7HT ENGLAND UNIV SCI & TECHNOL,SCH MED SCI,DEPT COMMUNITY HLTH KUMASI GHANA
Titolo Testata:
Transactions of the Royal Society of Tropical Medicine and Hygiene
fascicolo: 4, volume: 92, anno: 1998,
pagine: 407 - 410
SICI:
0035-9203(1998)92:4<407:EOTFBC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHATIC FILARIASIS; ENZYME-IMMUNOASSAY; COUNTING CHAMBER; DIAGNOSIS; MICROFILARIAE; PREVALENCE; INFECTION; ELISA; EPIDEMIOLOGY; SAMPLES;
Keywords:
FILARIASIS; WUCHERERIA BANCROFTI; DIAGNOSIS; OG4C3; ANTIGENEMIA; MICROFILAREMIA; FILTER PAPER; ENZYME-LINKED IMMUNOSORBENT ASSAY; GHANA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.O. Gyapong et al., "EVALUATION OF THE FILTER-PAPER BLOOD COLLECTION METHOD FOR DETECTING OG4C3 CIRCULATING ANTIGEN IN BANCROFTIAN FILARIASIS", Transactions of the Royal Society of Tropical Medicine and Hygiene, 92(4), 1998, pp. 407-410

Abstract

Serological diagnosis of filariasis is generally known to be more reliable than detection of microfilariae. The recently developed Og4C3 enzyme-linked immunosorbent assay (ELISA) for detecting Wuchereria bancrofti circulating antigen has been shown to be very sensitive in diagnosing filiariasis using serum samples. The commercially available form of this ELISA, using whole blood collected on filter paper, has not been validated independently. We evaluated the sensitivity of this new method against standard 20 mu L night blood films in 1808 paired samples from 18 communities in different endemic areas of Ghana. The diagnostic performance of the method was consistently low in all but: 2 communities (sensitivity=50.3%). This method of diagnosing filariasis is not suitable for field use in its present form.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:20:12