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Titolo:
PROLIFERATING CELL NUCLEAR ANTIGEN EXPRESSION IS INCREASED IN SMALL-BOWEL EPITHELIUM IN THE ELDERLY
Autore:
CORAZZA GR; GINALDI L; QUAGLIONE G; PONZIELLI F; VECCHIO L; BIAGI F; QUAGLINO D;
Indirizzi:
UNIV AQUILA,DIPARTIMENTO MED INTERNA,VIA S SISTO 22E I-67100 LAQUILA ITALY UNIV AQUILA,DIPARTIMENTO MED INTERNA I-67100 LAQUILA ITALY OSPED CIVILE I-64100 TERAMO ITALY
Titolo Testata:
Mechanism of ageing and development
fascicolo: 1, volume: 104, anno: 1998,
pagine: 1 - 9
SICI:
0047-6374(1998)104:1<1:PCNAEI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PCNA CYCLIN; MONOCLONAL-ANTIBODIES; COLONIC EPITHELIUM; BIOPSY SPECIMENS; RAT; AGE; MICROSCOPY; HUMANS; 19A2;
Keywords:
PCNA; ENTEROCYTE; ELDERLY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Corazza et al., "PROLIFERATING CELL NUCLEAR ANTIGEN EXPRESSION IS INCREASED IN SMALL-BOWEL EPITHELIUM IN THE ELDERLY", Mechanism of ageing and development, 104(1), 1998, pp. 1-9

Abstract

Although previous studies suggest that in aging animals the small intestine is in a hyperproliferative state, no information is currently available on the influence of age on the proliferation pattern of humansmall bowel enterocytes. The immunohistochemical expression of the proliferating cell nuclear antigen (PCNA), the villous height to total mucosal thickness ratio and the enterocyte height were evaluated in a panel of duodenal biopsy specimens obtained from 18 subjects aged less and 14 subjects aged more than 65 years. There was a significant positive correlation (P < 0.001) between age in years and percent of positive PCNA enterocytes both at the level of crypts (r(s) = 0.50) and villi (r(s) = 0.77). Moreover, the percentage of PCNA(+) enterocytes was significantly higher in elderly versus adult subjects, both at the level of villi (6.5 vs 0%; P < 0.001) and of crypts (40.0 vs 23.7%; P < 0.01). No correlation was found between the percentage of PCNA + enterocytes and enterocyte height or villous height to total mucosal thickness ratio. Our results show that PCNA reactivity increases with advancing age both in crypts and villi. This abnormality of the proliferation pattern may explain the coexistence of normal morphology and impaired absorptive function in the elderly. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:13:29