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Titolo:
E-CADHERIN EXPRESSION IS CORRELATED WITH THE ISOLATED CELL DIFFUSE HISTOTYPE AND WITH FEATURES OF BIOLOGICAL AGGRESSIVENESS OF GASTRIC-CARCINOMA
Autore:
MACHADO JC; CARNEIRO F; BECK S; ROSSI S; LOPES J; TAVEIRAGOMES A; CARDOSOOLIVEIRA M;
Indirizzi:
UNIV OPORTO,INST MOL PATHOL & IMMUNOL,FAC MED,RUA ROBERTO FRIAS S-N P-4200 OPORTO PORTUGAL UNIV TUBINGEN,INST ANTHROPOL & HUMAN GENET TUBINGEN GERMANY STATE RIO GRANDE SUL PORTO ALEGRE RS BRAZIL FAC MED PORTO,HS JOAO,DEPT PATHOL PORTO ALEGRE RS BRAZIL FAC MED PORTO,HS JOAO,DEPT SURG 3 PORTO ALEGRE RS BRAZIL
Titolo Testata:
International journal of surgical pathology
fascicolo: 3, volume: 6, anno: 1998,
pagine: 135 - 144
SICI:
1066-8969(1998)6:3<135:EEICWT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-CATENIN EXPRESSION; LOBULAR BREAST CANCERS; IMMUNOHISTOCHEMICAL EVALUATION; DOWN-REGULATION; ADHESION; INVASION; COMPLEX; TISSUES; TUMORS; MUTATIONS;
Keywords:
CANCER; CELL ADHESION; E-CADHERIN; GASTRIC CARCINOMA; PROGNOSIS; STOMACH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Machado et al., "E-CADHERIN EXPRESSION IS CORRELATED WITH THE ISOLATED CELL DIFFUSE HISTOTYPE AND WITH FEATURES OF BIOLOGICAL AGGRESSIVENESS OF GASTRIC-CARCINOMA", International journal of surgical pathology, 6(3), 1998, pp. 135-144

Abstract

We studied the pattern of immunohistochemical expression of E-cadherin in a series of 50 gastric carcinomas, aiming to analyze its relationship with histotype and features of biological aggressiveness of the tumors and survival of the patients. Abnormal E-cadherin expression wassignificantly (p=.0007) higher in diffuse/isolated-cell-type carcinomas than in intestinal/glandular carcinomas. In mixed carcinomas abnormal E-cadherin expression in the diffuse/isolated-cell-type component (94.4%) was significantly (p=.007) higher than in intestinal/glandular component (55.6%). Significant relationships were observed between abnormal E-cadherin expression and nodal metastases (p=.004) and pTNM stages (p=.05). Survival of patients with tumors displaying abnormal E-cadherin expression was worse than that of patients with tumors presenting normal expression, though not attaining the threshold of statistical significance (p=.19). We conclude that abnormal E-cadherin expression is correlated with diffuse/isolated-cell histotype and features of biological aggressiveness of gastric carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:03:56