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Titolo:
ANDROGEN RECEPTOR GENE ALTERATIONS ARE NOT ASSOCIATED WITH ISOLATED CRYPTORCHIDISM
Autore:
WIENER JS; MARCELLI M; GONZALES ET; ROTH DR; LAMB DJ;
Indirizzi:
BAYLOR COLL MED,LAB MALE REPROD RES,SCOTT DEPT UROL,DEPT CELL BIOL,1 BAYLOR PLAZA,ROOM 440E HOUSTON TX 77030 BAYLOR COLL MED,LAB MALE REPROD RES,SCOTT DEPT UROL,DEPT CELL BIOL HOUSTON TX 77030 BAYLOR COLL MED,DEPT MED,DIV ENDOCRINOL HOUSTON TX 77030 TEXAS CHILDRENS HOSP HOUSTON TX 77030
Titolo Testata:
The Journal of urology
fascicolo: 3, volume: 160, anno: 1998,
parte:, 1
pagine: 863 - 865
SICI:
0022-5347(1998)160:3<863:ARGAAN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; RAT GUBERNACULUM; FETAL-RAT; IDENTIFICATION; EXPRESSION; MUTATIONS; PROTEIN;
Keywords:
CRYPTORCHIDISM; RECEPTORS, ANDROGEN; TESTIS; BASE SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Wiener et al., "ANDROGEN RECEPTOR GENE ALTERATIONS ARE NOT ASSOCIATED WITH ISOLATED CRYPTORCHIDISM", The Journal of urology, 160(3), 1998, pp. 863-865

Abstract

Purpose: Multiple theories of testicular descent exist but there is no consensus. Cryptorchidism is a component of the androgen insensitivity syndrome, suggesting that testicular descent may be at least partially under the control of androgenic stimulation. To determine whether isolated cryptorchidism may be caused by androgen insensitivity, we screened a population of boys with isolated cryptorchidism for the presence of androgen receptor gene alterations. Materials and Methods: Deoxyribonucleic acid (DNA) was isolated from tissue collected from 21 patients with isolated cryptorchidism during orchiopexy. Patient selection was biased to maximize the likelihood of detection of a genetic etiology of cryptorchidism. The DNA was screened for androgen receptor gene alterations in exons 2 to fi using single strand conformational polymorphism analysis. Results: No abnormalities in the androgen receptor gene were detected by single strand conformational polymorphism analysis ill any patient. Conclusions: Mutations of the androgen receptor gene in the hormone and DNA binding domains of the protein appear to be an unlikely cause of isolated cryptorchidism.

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Documento generato il 29/11/20 alle ore 00:55:34