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Titolo:
MANAGEMENT OF THE ADVERSE-EFFECTS OF CLOZAPINE
Autore:
YOUNG CR; BOWERS MB; MAZURE CM;
Indirizzi:
YALE NEW HAVEN MED CTR,ADULT TREATMENT PROGRAM,20 YORK ST,EP 10-8 NEWHAVEN CT 06504 YALE NEW HAVEN MED CTR,ADULT TREATMENT PROGRAM NEW HAVEN CT 06504 YALE UNIV,SCH MED NEW HAVEN CT 06520
Titolo Testata:
Schizophrenia bulletin
fascicolo: 3, volume: 24, anno: 1998,
pagine: 381 - 390
SICI:
0586-7614(1998)24:3<381:MOTAOC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE SYMPTOMS; REFRACTORY SCHIZOPHRENIC-PATIENTS; INDUCED AGRANULOCYTOSIS; ORTHOSTATIC HYPOTENSION; CLINICAL-RESPONSE; WEIGHT-GAIN; INDUCED HYPERSALIVATION; UNITED-STATES; AKATHISIA; SEIZURES;
Keywords:
CLOZAPINE; ATYPICAL ANTIPSYCHOTICS; ADVERSE EFFECTS; SIDE EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
92
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Young et al., "MANAGEMENT OF THE ADVERSE-EFFECTS OF CLOZAPINE", Schizophrenia bulletin, 24(3), 1998, pp. 381-390

Abstract

Clozapine has been found to be superior to traditional neuroleptics in the treatment of refractory schizophrenia and is increasingly being used to treat schizophrenia, affective disorders, some neurological disorders, and aggression. For many patients, clozapine offers new hope for the successful pharmacological management of a disabling mental disorder However, up to 17 percent of patients must discontinue treatment with clozapine because of adverse effects, which also limit the rateat which the dose can be increased and the maximum dose that can be tolerated. This article reviews strategies for minimizing and managing the adverse effects of clozapine, including agranulocytosis, seizures,sedation, delirium, obsessive-compulsive symptoms, hypotension, tachycardia, weight gain, sialorrhea, elevated liver enzymes, constipation,nausea, enuresis, fever, and neuromuscular effects. Incidence and morbidity are presented first. Then, the known or hypothesized pathophysiology of the adverse effects are described. Finally, nonpharmacological and pharmacological interventions are reviewed. Understanding the incidence, pathophysiology, and treatments of adverse effects is essential for a positive therapeutic outcome when prescribing clozapine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:00:20