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Titolo:
POSITRON-EMISSION-TOMOGRAPHY STUDIES OF ABNORMAL GLUCOSE-METABOLISM IN SCHIZOPHRENIA
Autore:
BUCHSBAUM MS; HAZLETT EA;
Indirizzi:
MT SINAI SCH MED,DEPT PSYCHIAT,BOX 1505,1 GUSTAVE L LEVY PL NEW YORK NY 10029 MT SINAI SCH MED,NEUROSCI PET LAB NEW YORK NY 10029
Titolo Testata:
Schizophrenia bulletin
fascicolo: 3, volume: 24, anno: 1998,
pagine: 343 - 364
SICI:
0586-7614(1998)24:3<343:PSOAGI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; MAGNETIC-RESONANCE SPECTROSCOPY; OBSESSIVE-COMPULSIVE DISORDER; NEUROLEPTIC-NAIVE PATIENTS; NEVER-MEDICATED SCHIZOPHRENICS; HIGH-ENERGY PHOSPHATE; CARD SORT TEST; PREFRONTAL CORTEX; BASAL GANGLIA; SUSTAINED ATTENTION;
Keywords:
DEOXYGLUCOSE; FRONTAL LOBE; THALAMUS; STRIATUM; RECEPTOR LIGANDS; BRAIN IMAGING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
163
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Buchsbaum e E.A. Hazlett, "POSITRON-EMISSION-TOMOGRAPHY STUDIES OF ABNORMAL GLUCOSE-METABOLISM IN SCHIZOPHRENIA", Schizophrenia bulletin, 24(3), 1998, pp. 343-364

Abstract

Schizophrenia, a devastating disease characterized by a combination of various types of disturbed behaviors, thoughts, and feelings, may likewise be heterogeneous in etiology. Recent advances in neuroscience and psychopharmacology have suggested a wide array of competing mechanisms that may be involved in schizophrenia, including but not limited to deficits in one or more neurotransmitters and second messenger systems (e.g., dopamine, serotonin, gamma-aminobutyric acid, glutamate, andnoradrenalin), neurodevelopmental defects in brain circuitry, and viral infection. Psychiatric genetic studies indicate that schizophrenia is a disorder with multifactorial inheritance. Since cerebral metabolic activity reflects regional brain work for all neurotransmitter systems, imaging metabolism directly with fluorodeoxyglucose and indirectlywith blood flow and hemoglobin oxygen saturation can provide information about the functional neuroanatomy of a deficit in individual patients and allow patients to be grouped into more homogeneous subgroups for intensive study. This review summarizes metabolic imaging studies in schizophrenia over the past decade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 12:10:07