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Titolo:
PHARMACOKINETIC STUDY IN DOGS AND MONKEYS AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS OF [C-14]-ITF-296
Autore:
GIACHETTI C; BERTOLINO M; CANALI S; LOMBARDINI E; MONZANI MV; SALA A; ZANOLO G;
Indirizzi:
RBM SPA,IST RIC BIOMED A MARXER,VIA RIBES 1 I-10010 COLLERETTO GIACOSTO ITALY ITALFARMACO RES CTR I-20092 CINISELLO BALSAMO MI ITALY
Titolo Testata:
European journal of drug metabolism and pharmacokinetics
fascicolo: 2, volume: 23, anno: 1998,
pagine: 239 - 250
SICI:
0378-7966(1998)23:2<239:PSIDAM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Keywords:
ITF-296; DOG; MONKEY; PHARMACOKINETICS; PLASMA; EXCRETION BALANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
C. Giachetti et al., "PHARMACOKINETIC STUDY IN DOGS AND MONKEYS AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS OF [C-14]-ITF-296", European journal of drug metabolism and pharmacokinetics, 23(2), 1998, pp. 239-250

Abstract

Pharmacokinetics of [C-14]-ITF-296 and its metabolites, ITF-1124 and ITF-1577, were studied in dogs and monkeys after a single intravenous (2.5 mg/kg) and oral (10 mg/kg) administration. Radioactivity was measured by LSC while unchanged drug and its metabolites in plasma were assayed by an HPLC-UV method. The absorption of [C-14]-ITF-296 after oral administration is practically complete both in dogs and in monkeys. The determination of unchanged drug and its metabolites shows quite a similar profile in dogs and monkeys for ITF-296 and ITF-1124 and a different time-course for ITF-1577. Elimination of radioactivity occurs mainly in urine (namely 70-80%) for both species and the recovery of the dose (higher than 90%) takes place up to 96 h after both treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:27:58