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Titolo:
BETA-1 INTEGRIN DEFICIENCY IMPAIRS MIGRATION AND DIFFERENTIATION OF MOUSE EMBRYONIC STEM-CELL DERIVED NEURONS
Autore:
ANDRESSEN C; ARNHOLD S; PUSCHMANN M; BLOCH W; HESCHELER J; FASSLER R; ADDICKS K;
Indirizzi:
UNIV COLOGNE,INST ANAT 1,JOSEPH STELZMANN STR 9 D-50931 COLOGNE GERMANY UNIV COLOGNE,INST NEUROPHYSIOL D-50931 COLOGNE GERMANY UNIV LUND HOSP,DEPT EXPT PATHOL S-22185 LUND SWEDEN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 251, anno: 1998,
pagine: 165 - 168
SICI:
0304-3940(1998)251:3<165:BIDIMA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR-MATRIX MOLECULES; IN-VITRO; BETA(1) INTEGRINS; ADHESION; OUTGROWTH; LAMININ; ABSENCE; GROWTH; GENE;
Keywords:
EMBRYONIC STEM CELLS; CELL MATRIX INTERACTION; NEURONAL MIGRATION; NEURITE OUTGROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Andressen et al., "BETA-1 INTEGRIN DEFICIENCY IMPAIRS MIGRATION AND DIFFERENTIATION OF MOUSE EMBRYONIC STEM-CELL DERIVED NEURONS", Neuroscience letters, 251(3), 1998, pp. 165-168

Abstract

Cell-matrix interaction plays an important role during neuronal development, which is demonstrated by comparing wild type (D3)- and beta 1 integrin-deficient (G201) embryonic stem cell derived neurons. In D3 preparations complex networks of functionally coupled neurons with bi- and multipolar morphologies develop. In contrast, neuronal differentiation is retarded in G201 derived neurons, recognised by limited migration and restricted morphological differentiation. Furthermore, beta 1 integrin deficiency causes a delay in expression of major neurotransmitters like GABA and glutamate as well as of synaptophysin, These findings indicate a prominent role of beta 1 integrin for both morphological and chemical differentiation. (C) 1998 Elsevier Science Ireland Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:23:00