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Titolo:
A SUBSET OF NOTCH FUNCTIONS DURING DROSOPHILA EYE DEVELOPMENT REQUIRESU(H) AND THE E(SPL) GENE-COMPLEX
Autore:
LIGOXYGAKIS P; YU SY; DELIDAKIS C; BAKER NE;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOL GENET,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOL GENET BRONX NY 10461 FDN RES & TECHNOL HELLAS,INST MOL BIOL & BIOTECHNOL GR-71110 IRAKLIONGREECE UNIV CRETE,DEPT BIOL GR-71110 IRAKLION GREECE
Titolo Testata:
Development
fascicolo: 15, volume: 125, anno: 1998,
pagine: 2893 - 2900
SICI:
0950-1991(1998)125:15<2893:ASONFD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-VENTRAL BOUNDARY; LOOP-HELIX PROTEINS; OF-SPLIT COMPLEX; BHLH PROTEINS; CELL-FATE; TRANSCRIPTIONAL ACTIVATION; NEUROGENIC GENES; VESTIGIAL GENE; WING FORMATION; C-ELEGANS;
Keywords:
DROSOPHILA EYE; NOTCH; ENHANCER OF SPLIT; SUPPRESSOR OF HAIRLESS; ATONAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
P. Ligoxygakis et al., "A SUBSET OF NOTCH FUNCTIONS DURING DROSOPHILA EYE DEVELOPMENT REQUIRESU(H) AND THE E(SPL) GENE-COMPLEX", Development, 125(15), 1998, pp. 2893-2900

Abstract

The Notch signalling pathway is involved in many processes where cellfate is decided. Previous work showed that Notch is required at successive steps during R8 specification in the Drosophila eye. Initially, Notch enhances atonal expression and promotes atonal function. After atonal autoregulation has been established, Notch signalling represses atonal expression during lateral specification. In this paper we investigate which known components of the Notch pathway are involved in each signalling process. Using clonal analysis we show that a ligand of Notch, Delta, is required along with Notch for both proneural enhancement and lateral specification, while the downstream components Suppressor-of-Hairless and Enhancer-of-Split are involved only in lateral specification. Our data point to a distinct signal transduction pathway during proneural enhancement by Notch. Using misexpression experiments we also show that particular Enhancer-of-split bHLH genes can differ greatly in their contribution to lateral specification.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:30:50