Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MECHANISMS OF ACTION OF DISINFECTANTS
Autore:
DENYER SP; STEWART GSAB;
Indirizzi:
UNIV BRIGHTON,DEPT PHARM,LEWES RD BRIGHTON BN2 4GJ E SUSSEX ENGLAND UNIV NOTTINGHAM,DEPT PHARMACEUT SCI NOTTINGHAM NG7 2RD ENGLAND
Titolo Testata:
International biodeterioration & biodegradation
fascicolo: 3-4, volume: 41, anno: 1998,
pagine: 261 - 268
SICI:
0964-8305(1998)41:3-4<261:MOAOD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI; ALKYLTRIMETHYLAMMONIUM BROMIDES; ANTIMICROBIAL ACTIVITY; GROWTH-RATE; RESISTANCE; LETHALITY; BIOCIDES; SUSCEPTIBILITY; DESTRUCTION; CATALASE;
Keywords:
DISINFECTANTS; MODE OF ACTION; CELLULAR TARGETS; ANTIBACTERIAL ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Denyer e G.S.A.B. Stewart, "MECHANISMS OF ACTION OF DISINFECTANTS", International biodeterioration & biodegradation, 41(3-4), 1998, pp. 261-268

Abstract

Disinfectants and biocides are a chemically diverse group of agents which are generally considered to exhibit poor selective toxicity. Thisshould not be mistaken for poor target specificity, however, and muchis now known concerning the damaging interactions which may arise between bacterial cell and disinfectant agent. Critical governing features of these interactions are the physicochemical characteristics of thechemical agent, cell morphology, and the physiological status of the microorganism. Antibacterial events include membrane disruption, macromolecule dysfunction, and metabolic inhibition; the consequential effect is determined by the relative contribution(s) of the target(s) to microbial cell survival and the possible initiation of self-destructiveprocesses. Disinfection kinetics offer a measure to differentiate between physiochemical and chemical interactions. Increasingly demanding disinfectant applications require more sophisticated use of biocidal systems. Approaches include: agents in combination, whereby a knowledgeof mechanism of action assists in designing optimal mixtures; intracellular biocide delivery, using cellular transport processes to overcome cellular barriers; and targeted donation of biocide from delivery systems, requiring an understanding of target reactivity. A knowledge ofdisinfection mechanisms provides a basis from which novel chemistriesand synergistic combinations may be developed. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:58:06