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Titolo:
DISTRIBUTION OF PREPRO-NOCICEPTIN ORPHANIN FQ MESSENGER-RNA AND ITS RECEPTOR MESSENGER-RNA IN DEVELOPING AND ADULT-MOUSE CENTRAL NERVOUS SYSTEMS/
Autore:
IKEDA K; WATANABE M; ICHIKAWA T; KOBAYASHI T; YANO R; KUMANISHI T;
Indirizzi:
RIKEN,BRAIN SCI INST,LAB CELLULAR INFORMAT PROC,2-1 HIROSAWA WAKO SAITAMA 3510198 JAPAN HOKKAIDO UNIV,GRAD SCH MED,DIV BRAIN SCI,LAB MOL NEUROANAT SAPPORO HOKKAIDO 060863 JAPAN NIIGATA UNIV,BRAIN RES INST,DEPT MOL NEUROPATHOL NIIGATA 9518585 JAPAN
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 399, anno: 1998,
pagine: 139 - 151
SICI:
0021-9967(1998)399:1<139:DOPOFM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; MORPHINE-INDUCED ANALGESIA; PROTEIN-COUPLED RECEPTOR; ORPHAN OPIOID RECEPTOR; TISSUE DISTRIBUTION; MOLECULAR-CLONING; OPIATE RECEPTOR; GENE FAMILY; CHROMOSOMAL LOCALIZATION; REGIONAL DISTRIBUTION;
Keywords:
OPIOID; N/OFQ; IN SITU HYBRIDIZATION; INTERNEURON; ANALGESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
K. Ikeda et al., "DISTRIBUTION OF PREPRO-NOCICEPTIN ORPHANIN FQ MESSENGER-RNA AND ITS RECEPTOR MESSENGER-RNA IN DEVELOPING AND ADULT-MOUSE CENTRAL NERVOUS SYSTEMS/", Journal of comparative neurology, 399(1), 1998, pp. 139-151

Abstract

Nociceptin/orphanin FQ (N/OFQ) and its receptor share similarities toopioids and their receptors in terms of the molecular structure and signaling pathway, but the two systems exhibit different actions in vivo. To understand the mechanism of N/OFQ-system actions, we examined, by in situ hybridization analysis, the distribution of preproN/OFQ and N/OFQ receptor mRNAs in the developing and adult mouse central nervoussystems (CNS). In most neural regions, preproN/OFQ mRNA was mainly expressed in a small population of middle-sized neurons. These neurons were scattered between large projection-type neurons or within the neuropil, suggestive of interneurons. In some other nuclei (lateral septum, bed nucleus of the stria terminalis, reticular thalamic nucleus, inferior colliculus, and rostral periolivery nucleus), preproN/OFQ mRNA was expressed in a number of large projection-type neurons. By contrast, N/OFQ receptor mRNA was evenly expressed in most neurons of the adult CNS. Considering the inhibitory actions of N/OFQ, the distinct cellular expression pattern of the N/OFQ system suggests that the release of N/OFQ from interneurons may lower neuronal and synaptic activities of neighboring neurons, leading to integration or modulation of local circuits. Furthermore, the cellular expression pattern, distinct from that of the opioid system, may provide a possible molecular/cellular basis for the different in vivo actions of N/OFQ and opioids. In embryonic stages, both preproN/OFQ and N/OFQ receptor mRNAs were highly and widely expressed in the mantle zone, suggesting the possible importanceof N/OFQ signaling in CNS development. J. Comp. Neurol. 399:139-151, 1998. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:30:52