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Titolo:
REDUCED LEVELS OF GABA-BENZODIAZEPINE RECEPTOR IN ALCOHOL DEPENDENCY IN THE ABSENCE OF GREY-MATTER ATROPHY
Autore:
LINGFORDHUGHES AR; ACTON PD; GACINOVIC S; SUCKLING J; BUSATTO GF; BODDINGTON SJA; BULLMORE E; WOODRUFF PW; COSTA DC; PILOWSKY LS; ELL PJ; MARSHALL EJ; KERWIN RW;
Indirizzi:
INST PSYCHIAT,DEPT PSYCHOL MED,DE CRESPIGNY PK LONDON SE5 8AF ENGLAND UCL,SCH MED,INST NUCL MED LONDON ENGLAND UNIV LONDON KINGS COLL,SCH MED & DENT,CLIN AGE RES UNIT LONDON ENGLAND INST PSYCHIAT,DEPT PSYCHOL LONDON SE5 8AF ENGLAND UCL,SCH MED,INST NUCL MED LONDON ENGLAND MAUDSLEY HOSP & INST PSYCHIAT,NATL ALCOHOL UNIT LONDON SE5 8AZ ENGLAND
Titolo Testata:
British Journal of Psychiatry
, volume: 173, anno: 1998,
pagine: 116 - 122
SICI:
0007-1250(1998)173:<116:RLOGRI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING; NEUROTRANSMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Lingfordhughes et al., "REDUCED LEVELS OF GABA-BENZODIAZEPINE RECEPTOR IN ALCOHOL DEPENDENCY IN THE ABSENCE OF GREY-MATTER ATROPHY", British Journal of Psychiatry, 173, 1998, pp. 116-122

Abstract

Background We tested the hypothesis that reduced levels of the GABA-benzodiazepine receptor occur in alcohol dependency using single photonemission tomography (SPET) and the specific GABA-benzodiazepine ligand, (123I)-iomazenil. Method Neurologically and cognitively unimpaired abstinent alcohol-dependent (n=12) and non-alcohol-dependent male subjects (n=14) underwent a I-123-iomazenil SPET scan. SPET and magnetic resonance images were co-registered and voxel-based statistical tests performed. Subjects' clinical and alcohol history were obtained with standard questionnaires. The relationships between clinical and alcohol variables and the regional level of GABA-benzodiazepine receptors wereinvestigated using multiple regression analysis. Results Abstinent alcohol-dependent subjects had decreased levels of GABA- benzodiazepine receptor compared with non-alcohol-dependent subjects within the frontal, parietal and temporal cortices, including regions in which grey matter atrophy was absent, Conclusions Alcohol dependency is associated with reduced GABA-benzodiazepine receptor levels in the absence of grey matter atrophy in some cortical regions, such as within the parietalrobe. Regional variability of reduction in GABA-benzodiazepine receptors demonstrates that alcohol does not have a global, toxic effect on the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:12:04