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Titolo:
ABNORMAL VASCULAR-RESPONSES IN HUMAN CHRONIC CARDIAC-FAILURE ARE BOTHENDOTHELIUM-DEPENDENT AND ENDOTHELIUM-INDEPENDENT
Autore:
MAGUIRE SM; NUGENT AG; MCGURK C; JOHNSTON GD; NICHOLLS DP;
Indirizzi:
ROYAL VICTORIA HOSP,DEPT MED,INST CLIN SCI BELFAST BT12 6BA ANTRIM NORTH IRELAND ROYAL VICTORIA HOSP,DEPT MED,INST CLIN SCI BELFAST BT12 6BA ANTRIM NORTH IRELAND QUEENS UNIV BELFAST,DEPT THERAPEUT BELFAST ANTRIM NORTH IRELAND
Titolo Testata:
HEART
fascicolo: 2, volume: 80, anno: 1998,
pagine: 141 - 145
SICI:
1355-6037(1998)80:2<141:AVIHCC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; CONVERTING ENZYME-INHIBITORS; NITRIC-OXIDE PRODUCTION; MEDIATED VASODILATION; CORONARY ATHEROSCLEROSIS; CONSCIOUS DOGS; VASOMOTOR TONE; HUMAN FOREARM; BLOOD-FLOW; SEROTONIN;
Keywords:
HEART FAILURE; ENDOTHELIUM; NITRATES; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Maguire et al., "ABNORMAL VASCULAR-RESPONSES IN HUMAN CHRONIC CARDIAC-FAILURE ARE BOTHENDOTHELIUM-DEPENDENT AND ENDOTHELIUM-INDEPENDENT", HEART, 80(2), 1998, pp. 141-145

Abstract

Objective-To study underlying vascular responses in chronic heart failure in patients without ACE inhibitor treatment, and to compare them with age matched controls. Design-Forearm blood flow was studied usingvenous occlusion plethysmography in patients with chronic :heart failure (n = 12) and matched controls (n = 13), after infusion of L-NMMA (a nitric oxide synthase inhibitor), glyceryl trinitrate tan endothelium independent vasodilator), and serotonin tan endothelium dependent vasodilator). Results-NMMA produced significant vasoconstriction in normal subjects (forearm blood flow reduced by:24%), but not in patients (6%; difference between groups p < 0.03). The vasodilator responses to glyceryl trinitrate were impaired in patients (p < 0.02). In normal controls, serotonin produced initial dilatation, followed by vasoconstriction at high doses. In patients, no vasodilator responses were observed, only late vasoconstriction (p < 0.03). Conclusions-The vascular responses of patients are confirmed as being abnormal. The lack of response to L-NMMA suggests that nitric oxide does not contribute to basal vascular tone in patients with chronic heart failure. The responses toglyceryl trinitrate and to serotonin suggest that there is both smooth muscle and endothelial dysfunction in patients with chronic heart failure.

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Documento generato il 21/09/20 alle ore 03:23:46