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Titolo:
MEMORY FOR EMOTIONAL EVENTS - DIFFERENTIAL-EFFECTS OF CENTRALLY VERSUS PERIPHERALLY ACTING BETA-BLOCKING-AGENTS
Autore:
VANSTEGEREN AH; EVERAERD W; CAHILL L; MCGAUGH JL; GOOREN LJG;
Indirizzi:
UNIV AMSTERDAM,DEPT CLIN PSYCHOL,ROETERSSTR 15 NL-1018 WB AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT CLIN PSYCHOL NL-1018 WB AMSTERDAM NETHERLANDS UNIV CALIF IRVINE,DEPT PSYCHOBIOL,CTR NEUROBIOL LEARNING & MEMORY IRVINE CA 92717 VRIJE UNIV AMSTERDAM,ACAD HOSP,DEPT INTERNAL MED AMSTERDAM NETHERLANDS
Titolo Testata:
Psychopharmacology
fascicolo: 3-4, volume: 138, anno: 1998,
pagine: 305 - 310
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE RESPONSES; AMYGDALA; BLOCKERS; SYSTEM;
Keywords:
MEMORY; AROUSAL; EMOTION; BETA-ADRENERGIC ACTIVATION; BETA-BLOCKER; PROPRANOLOL; NADOLOL MEMORY FOR EMOTIONAL EVENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A.H. Vanstegeren et al., "MEMORY FOR EMOTIONAL EVENTS - DIFFERENTIAL-EFFECTS OF CENTRALLY VERSUS PERIPHERALLY ACTING BETA-BLOCKING-AGENTS", Psychopharmacology, 138(3-4), 1998, pp. 305-310

Abstract

Substantial evidence from animal research indicates that enhanced memory associated with emotional experiences involves activation of the beta-adrenergic system. This hypothesis is further supported by the finding in human subjects that blockade of beta-adrenergic receptors withpropranolol selectively reduced memory for emotional events. In the present study, we compared the effects of propranolol, a lipid soluble drug which crosses the blood-brain barrier easily, with those of nadolol, a water soluble drug which crosses the blood-brain barrier to a considerably lesser extent, to determine whether the effect involved peripheral or central beta-adrenergic receptors. tors. The effects of these drugs, taken before subjects watched a slide show that was either emotionally arousing or relatively neutral in content, were tested 1 week later with a surprise memory test. Consistent with previous results, propranolol impaired memory (recall and recognition) in the subjectswho saw the emotional version of the slide show. In contrast, nadololdid not impair memory of the emotional slide show. These results indicate that the blockade of central beta-adrenergic receptors is responsible for the reduction in storage of emotional events. The results support the view that memory of a mild emotional event involves activation of central, but not necessarily peripheral beta-adrenergic receptors.

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Documento generato il 03/12/20 alle ore 15:03:58