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Titolo:
MOLECULAR PATHOLOGY OF OVARIAN CARCINOMAS
Autore:
MATIASGUIU X; PRAT J;
Indirizzi:
UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,DEPT PATHOL,AVDA SANT ANTONI M CLARET 167 E-08025 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,DEPT PATHOL E-08025 BARCELONA SPAIN
Titolo Testata:
Virchows Archiv
fascicolo: 2, volume: 433, anno: 1998,
pagine: 103 - 111
SICI:
0945-6317(1998)433:2<103:MPOOC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER SUSCEPTIBILITY GENE; STAGE-I CARCINOMAS; P53 GENE; BREAST-CANCER; TELOMERASE ACTIVITY; MICROSATELLITE INSTABILITY; PROGNOSTIC-SIGNIFICANCE; RETINOBLASTOMA GENE; ENDOMETRIAL CARCINOMA; CLINICAL IMPLICATIONS;
Keywords:
OVARY; ONCOGENES; TUMOR SUPPRESSOR GENES; PATHOGENESIS; TUMORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
92
Recensione:
Indirizzi per estratti:
Citazione:
X. Matiasguiu e J. Prat, "MOLECULAR PATHOLOGY OF OVARIAN CARCINOMAS", Virchows Archiv, 433(2), 1998, pp. 103-111

Abstract

There is evidence that ovarian cancer may be derived from the progressive transformation of benign and/or borderline tumours. Mutations involving different oncogenes and tumour suppressor genes accumulate during the process of malignant transformation, and the alterations of genes involved in the pathogenesis of familial ovarian cancer are probably early events in ovarian tumorigenesis. BRCA-1 and BRCA-2 act as classical tumour suppressor genes in hereditary tumours, but their role insporadic tumours remains controversial; however, a high frequency of allele losses in BRCA-1 (17q) and BRCA-2 (13q) loci has been observed in both familial and sporadic tumours. The possible role of mismatch repair genes and microsatellite instability is also controversial, but a role for them has been proposed in borderline tumours. Mutations in K-ms are specific for mucinous tumours and may be related to mucinous differentiation. Finally, a role in tumour progression has been proposed fdr both c-erb B-2 and p53, but their practical value in prognosis remains questionable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:30:48