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Titolo:
A PLACEBO-CONTROLLED TRIAL OF INSULIN-LIKE GROWTH-FACTOR-I IN AMYOTROPHIC-LATERAL-SCLEROSIS
Autore:
BORASIO GD; ROBBERECHT W; LEIGH PN; EMILE J; GUILOFF RJ; JERUSALEM F; SILANI V; VOS PE; WOKKE JHJ; DOBBINS T;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL D-81366 MUNICH GERMANY UNIV MUNICH,DEPT NEUROL D-80539 MUNICH GERMANY KATHOLIEKE UNIV LEUVEN,DEPT NEUROL B-3001 LEUVEN BELGIUM INST PSYCHIAT,DEPT CLIN NEUROSCI LONDON ENGLAND UNIV LONDON KINGS COLL,SCH MED & DENT LONDON ENGLAND UNIV AMSTERDAM,ACAD MED CTR,LAB EXPT NEUROL NL-1105 AZ AMSTERDAM NETHERLANDS UNIV ANGERS,MED CTR,DEPT NEUROL B ANGERS FRANCE UNIV BONN,DEPT NEUROL D-5300 BONN GERMANY CHARING CROSS HOSP,NEUROMUSCULAR UNIT LONDON ENGLAND UNIV MILAN,IRCCS,OSPED MAGGIORE,DEPT NEUROL I-20122 MILAN ITALY UNIV UTRECHT,DIV NEUROMUSCULAR DIS NL-3508 TC UTRECHT NETHERLANDS CEPHALON INC W CHESTER PA 00000
Titolo Testata:
Neurology
fascicolo: 2, volume: 51, anno: 1998,
pagine: 583 - 586
SICI:
0028-3878(1998)51:2<583:APTOIG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHCNTF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
G.D. Borasio et al., "A PLACEBO-CONTROLLED TRIAL OF INSULIN-LIKE GROWTH-FACTOR-I IN AMYOTROPHIC-LATERAL-SCLEROSIS", Neurology, 51(2), 1998, pp. 583-586

Abstract

To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure (change in disease progression as assessed by the Appel ALS rating scale) showed no significant difference between treatment groups. RhIGF-I appeared to be safe and well-tolerated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:49:43