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Titolo:
MATHEMATICAL-MODEL OF 5-[I-125]IODO-2'-DEOXYURIDINE TREATMENT - CONTINUOUS-INFUSION REGIMENS FOR HEPATIC METASTASES
Autore:
SGOUROS G; ODONOGHUE JA; LARSON SM; MACAPINLAC H; LARSON JJ; KEMENY N;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT MED PHYS,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT RADIOL,NUCL MED SERV NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT MED,GASTROINTESTINAL & SOLID TUMOR SERV NEW YORK NY 10021
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 5, volume: 41, anno: 1998,
pagine: 1177 - 1183
SICI:
0360-3016(1998)41:5<1177:MO5T-C>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUGER-ELECTRON EMITTERS; COLORECTAL-CANCER; MAMMALIAN-CELLS; RADIOTOXICITY; IODODEOXYURIDINE; RADIOTHERAPY; LIVER; 5-)I-123>IODO-2'-DEOXYURIDINE; I-125; HETEROGENEITY;
Keywords:
IODODEOXYURIDINE; (125)IODINE; HEPATIC ARTERY INFUSION; TREATMENT PLANNING; MODELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
G. Sgouros et al., "MATHEMATICAL-MODEL OF 5-[I-125]IODO-2'-DEOXYURIDINE TREATMENT - CONTINUOUS-INFUSION REGIMENS FOR HEPATIC METASTASES", International journal of radiation oncology, biology, physics, 41(5), 1998, pp. 1177-1183

Abstract

Purpose: Due to the cytotoxicity of DNA-bound iodine-125, 5-[I-125]Iodo-2'-deoxyuridine ([I-125]IUdR), an analog of thymidine, has long been recognized as possessing therapeutic potential, In this work, the feasibility and potential effectiveness of hepatic artery infusion of [I-125]IUdR is examined. Methods: A mathematical model has been developed that simulates tumor growth and response to [125I]IUdR treatment. The model is used to examine the efficacy and potential toxicity of prolonged infusion therapy, Treatment of kinetically homogeneous tumors with potential doubling times of either 4, 5, or 6 days is simulated, Assuming uniformly distributed activity, absorbed dose estimates to the red marrow, liver and whole-body are calculated to assess the potential toxicity of treatment. Results: Nine to 10 logs of tumor-cell kill over a 7- to 20-day period are predicted by the various simulations examined, The most slowly proliferating tumor was also the most difficultto eradicate, During the infusion time, tumor-cell loss consisted of two components: A plateau phase, beginning at the start of infusion and ending once the infusion time exceeded the potential doubling time of the tumor; and a rapid cell-reduction phase that was close to log-linear. Beyond the plateau phase, treatment efficacy was highly sensitive to tumor activity concentration, Conclusions: Model predictions suggest that [I-125]IUdR Will be highly dependent upon the potential doubling time of the tumor, Significant tumor cell kill will require infusion durations that exceed the longest potential doubling time in the tumor-cell population. (C) 1998 Elsevier Science Inc.

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Documento generato il 29/03/20 alle ore 18:15:54