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Titolo:
FAMILIAL AGGREGATION OF COLORECTAL-CANCER IN EGYPT
Autore:
SOLIMAN AS; BONDY ML; LEVIN B; ELBADAWY S; KHALED H; HABLAS A; ISMAIL S; ADLY M; MAHGOUB KG; MCPHERSON RS; BEASLEY RP;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT EPIDEMIOL,1515 HOLCOMBE BLVD,BOX 189 HOUSTON TX 77030 UNIV TEXAS,MD ANDERSON CANCER CTR,DIV CANC PREVENT HOUSTON TX 77030 MENOFEIA FAC MED,DEPT COMMUNITY MED MENOUFIA EGYPT CAIRO UNIV,NATL CANC INST CAIRO EGYPT CAIRO UNIV,DEPT OCCUPAT MED CAIRO EGYPT TANTA CANC CTR TANTA EGYPT UNIV TEXAS,SCH PUBL HLTH HOUSTON TX 77030
Titolo Testata:
International journal of cancer
fascicolo: 6, volume: 77, anno: 1998,
pagine: 811 - 816
SICI:
0020-7136(1998)77:6<811:FAOCIE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR SPECTRUM; 3-YEAR EXPERIENCE; COLON CANCER; FREQUENCY; WATER; GENETICS; KINDREDS; DISEASE; HNPCC; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Soliman et al., "FAMILIAL AGGREGATION OF COLORECTAL-CANCER IN EGYPT", International journal of cancer, 77(6), 1998, pp. 811-816

Abstract

We have investigated the familial aggregation of colorectal cancer and hereditary nonpolyposis colorectal cancer (HNPCC) in Egypt because of the high incidence of colorectal cancer in Egyptian children and young adults and the prevalence of consanguinity there. In a pilot study,we conducted detailed interviews with I I I Egyptian colorectal cancer patients and I I I healthy Egyptian controls about their family histories of colorectal cancer, and other cancers, consanguinity, age at diagnosis, symptoms and recurrence. Eight patients (7.2%) had one or more first- or second-degree relatives under age 40 with colorectal cancer, suggestive of HNPCC by the Amsterdam criteria. One of these families had a typical history of HNPCC, with 4 relatives having colorectal cancer in 3 generations; 3 of these relatives were younger than age 45at colon cancer diagnosis, and other relatives had extracolonic tumors. Another 14 patients (12.6%) had a first- or second-degree relative with a family history of other neoplasms such as endometrial, urinary and hepatobiliary cancers that could also be related to HNPCC. Four patients with early-onset colon cancer and a family history of other HNPCC-related cancers reported that their parents were first-degree cousins. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:00:38