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Titolo:
EXPRESSION OF ATP-GATED ION CHANNELS BY REISSNERS MEMBRANE EPITHELIAL-CELLS
Autore:
KING M; HOUSLEY GD; RAYBOULD NP; GREENWOOD D; SALIH SG;
Indirizzi:
UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PHYSIOL,MOL PHYS LAB,PRIVATE BAG 92019 AUCKLAND 1 NEW ZEALAND UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PHYSIOL,MOL PHYS LAB AUCKLAND 1NEW ZEALAND
Titolo Testata:
NeuroReport
fascicolo: 11, volume: 9, anno: 1998,
pagine: 2467 - 2474
SICI:
0959-4965(1998)9:11<2467:EOAICB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; HAIR-CELLS; P2X(2) RECEPTOR; NONSELECTIVE CATION; SENSORY NEURONS; P-2X RECEPTOR; SUBUNIT; LOCALIZATION; CL;
Keywords:
ADENOSINE 5'-TRIPHOSPHATE; ATP-GATED ION CHANNEL; COCHLEA; P2X RECEPTOR; REISSNERS MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. King et al., "EXPRESSION OF ATP-GATED ION CHANNELS BY REISSNERS MEMBRANE EPITHELIAL-CELLS", NeuroReport, 9(11), 1998, pp. 2467-2474

Abstract

REISSNER'S membrane forms a partition between the endolymphatic and perilymphatic cochlear compartments. Expression of the P2X(2) receptor subunit which assembles to form ATP-gated ion channels was detected inguinea-pig Reissner's membrane using the reverse transcription polymerase chain reaction (RT-PCR). The P2X(2) receptor subunit protein was localized to the epithelial cells which line the endolymphatic surfaceof Reissner's membrane using confocal immunofluorescence. The P2X receptor expression in Reissner's membrane was functionally confirmed using whole-cell voltage-clamp. An inwardly rectifying conductance was activated in Reissner's membrane epithelial cells in the presence of extracellular ATP (100 mu M). This conductance had a pharmacological profile compatible with the P2X, receptor designation, but exhibited substantial desensitisation which may be attributable to additional P2X receptor subunits. This study indicates that extracellular ATP, a humoralfactor within scala media, acts via ATP-gated ion channels expressed by Reissner's membrane epithelial cells to decrease the driving force for sound transduction. NeuroReport 9: 2467-2474 (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:17:07