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Titolo:
LEUCINE-BASED RECEPTOR SORTING MOTIFS ARE DEPENDENT ON THE SPACING RELATIVE TO THE PLASMA-MEMBRANE
Autore:
GEISLER C; DIETRICH J; NIELSEN BL; KASTRUP J; LAURITSEN JPH; ODUM N; CHRISTENSEN MD;
Indirizzi:
UNIV COPENHAGEN,PANUM INST,INST MED MICROBIOL & IMMUNOL,BLDG 18-3,BLEGDAMSVEJ 3C DK-2200 COPENHAGEN DENMARK
Titolo Testata:
The Journal of biological chemistry
fascicolo: 33, volume: 273, anno: 1998,
pagine: 21316 - 21323
SICI:
0021-9258(1998)273:33<21316:LRSMAD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; COATED PIT ADAPTINS; FACTOR-II RECEPTOR; CYTOPLASMIC DOMAIN; CARBOXYL-TERMINUS; INVITRO BINDING; INVARIANT CHAIN; DOWN-REGULATION; INTERNALIZATION; CD3-GAMMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C. Geisler et al., "LEUCINE-BASED RECEPTOR SORTING MOTIFS ARE DEPENDENT ON THE SPACING RELATIVE TO THE PLASMA-MEMBRANE", The Journal of biological chemistry, 273(33), 1998, pp. 21316-21323

Abstract

Many integral membrane proteins contain leucine-based motifs within their cytoplasmic domains that mediate internalization and intracellular sorting. Two types of leucine-based motifs have been identified. Onetype is dependent on phosphorylation, whereas the other type, which includes an acidic amino acid, is constitutively active. In this study,we have investigated how the spacing relative to the plasma membrane affects the function of both types of leucine-based motifs, For phosphorylation-dependent leucine-based motifs, a minimal spacing of 7 residues between the plasma membrane and the phospho-acceptor was required for phosphorylation and thereby activation of the motifs. For constitutively active leucine-based motifs, a minimal spacing of 6 residues between the plasma membrane and the acidic residue was required for optimal activity of the motifs. In addition, we found that the acidic residue of leucine-based motifs must be located amino-terminal to the dileucine sequence for proper function of the motifs and that residues surrounding the motifs affect the activity of the motifs, Thus, our observations suggest that the position, the exact sequence, and surroundingresidues are major determinants of the function of leucine-based receptor sorting motifs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:29:27