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Titolo:
UP-REGULATION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR INDUCED BY HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR STIMULATION IN HUMAN GLIOMA-CELLS
Autore:
MORIYAMA T; KATAOKA H; HAMASUNA R; YOKOGAMI K; UEHARA H; KAWANO H; GOYA T; TSUBOUCHI H; KOONO M; WAKISAKA S;
Indirizzi:
MIYAZAKI MED COLL,DEPT NEUROSURG,5200 KIHARA MIYAZAKI 88916 JAPAN MIYAZAKI MED COLL,DEPT PATHOL 2 MIYAZAKI 88916 JAPAN MIYAZAKI MED COLL,DEPT INTERNAL MED 2 MIYAZAKI 88916 JAPAN
Titolo Testata:
Biochemical and biophysical research communications (Print)
fascicolo: 1, volume: 249, anno: 1998,
pagine: 73 - 77
SICI:
0006-291X(1998)249:1<73:UOVEGI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY FACTOR; FACTOR EXPRESSION; IN-VIVO; TUMOR ANGIOGENESIS; BRAIN-TUMORS; FACTOR HGF; MET; PURIFICATION; RECEPTOR; MOTILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
T. Moriyama et al., "UP-REGULATION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR INDUCED BY HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR STIMULATION IN HUMAN GLIOMA-CELLS", Biochemical and biophysical research communications (Print), 249(1), 1998, pp. 73-77

Abstract

Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) contributes to the malignant progression of human gliomas. Weinvestigated the effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of c-Met/HGF receptor-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of VEGF proteins accompanying increased transcription of VEGF mRNA in a dose-dependent fashion. Sincemalignant gliomas frequently co-express HGF/SF and its receptor, these results suggest that HGF/SF could act as an indirect angiogenic factor through autocrine induction of VEGF expression and secretion in malignant gliomas. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:57:52