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Titolo:
DISCRIMINATION OF 2 AMINO-ACID-TRANSPORT ACTIVITIES IN 4F2 HEAVY EXPRESSING XENOPUS-LAEVIS OOCYTES
Autore:
BROER A; HAMPRECHT B; BROER S;
Indirizzi:
UNIV TUBINGEN,INST PHYS CHEM,HOPPE SEYLER STR 4 D-72076 TUBINGEN GERMANY UNIV TUBINGEN,INST PHYS CHEM D-72076 TUBINGEN GERMANY
Titolo Testata:
Biochemical journal
, volume: 333, anno: 1998,
parte:, 3
pagine: 549 - 554
SICI:
0264-6021(1998)333:<549:DO2AAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-ANTIGEN; SYSTEM Y(+)L; RAT-KIDNEY; RENAL REABSORPTION; HUMAN ERYTHROCYTES; MOUSE BLASTOCYSTS; MESSENGER-RNA; CYSTINE; CHAIN; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A. Broer et al., "DISCRIMINATION OF 2 AMINO-ACID-TRANSPORT ACTIVITIES IN 4F2 HEAVY EXPRESSING XENOPUS-LAEVIS OOCYTES", Biochemical journal, 333, 1998, pp. 549-554

Abstract

Expression of the type II membrane proteins of the rbAT/4F2hc family in Xenopus laevis oocytes results in the induction of amino acid transport activity. To elucidate the mechanism of action, amino acid transport was investigated in oocytes expressing the surface antigen 4F2hc. Leucine transport was mediated by a Na+-independent and a Na+-dependent transport mechanism. Both systems could be further discriminated by their stereochemical constraints. Isoleucine, with a branch at the beta-position, shared only the Na+-independent transport system with leucine. Both transport systems were sensitive to inhibition by arginine, but only the Na+-independent system was sensitive to inhibition by 2-aminobicyclo[2,2, 1]heptane-2-carboxylic acid. When compared with knowntransport systems the two transport activities could be described as similar to, but not identical with, mammalian systems b(0,+) and y(+)L. The Na+-independent b(0,+)-like transport system was found both in rbAT and 4F2hc expressing oocytes, indicating that both proteins act ina similar way.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:31:29