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Titolo:
BODY-FLUID MARKERS TO MONITOR MULTIPLE-SCLEROSIS - THE ASSAYS AND THECHALLENGES
Autore:
LAMAN JD; THOMPSON EJ; KAPPOS L;
Indirizzi:
ERASMUS UNIV,DEPT IMMUNOL,POB 1738 NL-3000 DR ROTTERDAM NETHERLANDS TNO,PREVENT & HLTH,PG,DIV INFECT DIS & IMMUNOL NL-2301 CE LEIDEN NETHERLANDS NATL HOSP NEUROL & NEUROSURG LONDON WC1N 3BG ENGLAND UNIV BASEL,KANTONSSPITAL,NEUROL KLIN CH-4031 BASEL SWITZERLAND
Titolo Testata:
Multiple sclerosis
fascicolo: 3, volume: 4, anno: 1998,
pagine: 266 - 269
SICI:
1352-4585(1998)4:3<266:BMTMM->2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE ADHESION MOLECULES; PROTEIN-LIKE MATERIAL; CEREBROSPINAL-FLUID; PUNCTURE HEADACHE; CORRELATE; LESIONS; NEEDLE; MRI;
Keywords:
ANTIBODY; CSF (CEREBROSPINAL FLUID); MMP (MATRIX METALLOPROTEINASE); NITRIC OXIDE; SERUM; T CELLS; URINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Laman et al., "BODY-FLUID MARKERS TO MONITOR MULTIPLE-SCLEROSIS - THE ASSAYS AND THECHALLENGES", Multiple sclerosis, 4(3), 1998, pp. 266-269

Abstract

The need for reliable markers of disease activity in multiple sclerosis (MS) to better guide basic research, diagnosis, treatment, and monitoring of therapy is well-recognized A recent European Charcot Foundation Symposium (Body fluid markers for course and activity of disease in multiple sclerosis (Madrid, Spain, October 2-4, 1997) organized by the European Charcot Foundation and the Fundacion Espanola de Esclerosis Multiple (the Spanish Multiple Sclerosis Foundation) brought together experts in the field to review the state of the art for the technology measuring markers in body fluids. An array of different approaches was presented to measure a wide diversity of classic and novel marker molecules, including cytokines, adhesion molecules, myelin compounds, and Fee antibody light chains, in either blood, urine, or cerebrospinal fluid. Here, recent progress in these approaches is assessed in the context of distinct pathophysiological stages of the disease, the requirements which such molecules and assays should ideally meet, and the practical and conceptual challenges which they face. Recommendations for further improvements ore described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:25:18