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Titolo:
EFFECTS OF MOLYBDATE AND PENTACHLOROPHENOL ON THE SULFATION OF DEHYDROEPIANDROSTERONE
Autore:
BOLES JW; KLAASSEN CD;
Indirizzi:
UNIV KANSAS,MED CTR,CTR ENVIRONM & OCCUPAT HLTH,DEPT PHARMACOL TOXICOL & THERAPEUT KANSAS CITY KS 66160
Titolo Testata:
Toxicology and applied pharmacology
fascicolo: 1, volume: 151, anno: 1998,
pagine: 105 - 109
SICI:
0041-008X(1998)151:1<105:EOMAPO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE 3'-PHOSPHATE 5'-PHOSPHOSULFATE; RAT-LIVER; INORGANIC SULFATE; SEX-DIFFERENCES; SULFOTRANSFERASE; INVIVO; ACETAMINOPHEN; IMPAIRS; HARMOL; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Boles e C.D. Klaassen, "EFFECTS OF MOLYBDATE AND PENTACHLOROPHENOL ON THE SULFATION OF DEHYDROEPIANDROSTERONE", Toxicology and applied pharmacology, 151(1), 1998, pp. 105-109

Abstract

Pentachlorophenol (PCP) and molybdate have been shown to inhibit the sulfoconjugation of various chemicals in rats and therefore are usefulto examine the role of sulfoconjugation on the toxicity of a chemical, PCP inhibits sulfation by competing with substrates for phenol-sulfotransferases, but not hydroxysteroid-sulfotransferases. In contrast, molybdate decreases sulfation by limiting sulfate availability and thereby decreasing the synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), which is the obligate cosubstrate for sulfation. Therefore, itwas of interest to determine whether PCP or molybdate is effective indecreasing the in vivo sulfation of dehydroepiandrosterone (DHEA), which is a substrate for hydroxysteroid-sulfotransferases. PCP (40 mu mol/kg ip) or molybdate (7.5 mmol/kg po) was given 45 min and 4 h, respectively, prior to the start of DHEA infusion. The effects of these twosulfation inhibitors on DHEA sulfation were dependent on the rate of DHEA infusion in rats. PCP had different effects on the sulfation of various infusion rates of DHEA in rats. PCP had little effect on the sulfation after the two lowest infusion rates of DHEA (12.5 and 25 mg/kg) and actually increased (233%) DHEA-sulfate serum concentrations withthe highest DHEA infusion rate (50 mg/kg). Although molybdate had little affect on the sulfation of the lowest DHEA infusion rate, it significantly decreased (50-85%) DHEA-sulfate serum concentrations with thetwo higher DHEA infusion rates. These data indicate that molybdate, unlike PCP, decreases the sulfation of DHEA and may be a useful tool todecrease the sulfation of other substrates of hydroxysteroid-sulfotransferases. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:38:39