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Titolo:
PROSPECTS FOR THE PHARMACOLOGICAL TREATMENT OF HUMAN PRION DISEASES
Autore:
ADJOU KT; DESLYS JP; DEMAIMAY R; SEMAN M; DORMONT D;
Indirizzi:
CRSSA,CEA,SERV NEUROVIROL,DEPT RECH MED,DSV,DRM,BP 6,60-68 AVE GEN LECLERC F-92265 FONTENAY ROSES FRANCE UNIV PARIS 07,LAB IMMUNODIFFERENCIAT PARIS FRANCE
Titolo Testata:
CNS drugs
fascicolo: 2, volume: 10, anno: 1998,
pagine: 83 - 89
SICI:
1172-7047(1998)10:2<83:PFTPTO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREUTZFELDT-JAKOB-DISEASE; SCRAPIE-INFECTED HAMSTERS; FIBRILLARY ACIDIC PROTEIN; AMPHOTERICIN-B; AGENT REPLICATION; INCUBATION PERIOD; PRP ACCUMULATION; VARIANT CJD; MS-8209; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K.T. Adjou et al., "PROSPECTS FOR THE PHARMACOLOGICAL TREATMENT OF HUMAN PRION DISEASES", CNS drugs, 10(2), 1998, pp. 83-89

Abstract

There is currently no effective therapy available for Creutzfeldt-Jakob disease and related prion disorders. However, a limited number of drugs have been found to affect the course of experimental prion diseases and to modify the kinetics of abnormal prion protein accumulation in the CNS. These include polyanions, the amyloid-binding dye Congo red, amphotericin B and its derivatives and, more recently, anthracyclines. At present, the most promising agent appears to be the amphotericinB derivative MS-8209. As a result of its wide spectrum of anti scrapie activity and efficacy in early and late stages of the incubation period of the disease in experimental prion models, MS-8209 could be usedas a pharmacological tool to contribute to our understanding of the pathogenic mechanisms involved in these neurodegenerative disorders andto afford a new and valuable base for future therapeutic strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:38:43