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Titolo:
DIFFERENTIAL PARTICIPATION OF HIPPOCAMPAL-FORMATION IN COCAINE-INDUCED CORTICAL ELECTROENCEPHALOGRAPHIC DESYNCHRONIZATION AND PENILE ERECTION IN THE RAT
Autore:
CHANG AYW; CHAN JYH; TSEN LY; CHAN SHH;
Indirizzi:
NATL SUN YAT SEN UNIV,CTR NEUROSCI KAOHSIUNG 80424 TAIWAN NATL YANG MING UNIV,INST PHARMACOL TAIPEI 11221 TAIWAN NATL YANG MING UNIV,CTR NEUROSCI TAIPEI 11221 TAIWAN VET GEN HOSP,DEPT MED RES TAIPEI 11217 TAIWAN
Titolo Testata:
Synapse
fascicolo: 2, volume: 30, anno: 1998,
pagine: 140 - 149
SICI:
0887-4476(1998)30:2<140:DPOHIC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POWER SPECTRAL-ANALYSIS; MEDIAL PREFRONTAL CORTEX; SEXUAL DYSFUNCTION; EXTRACELLULAR NOREPINEPHRINE; LOCUS-COERULEUS; NITRIC-OXIDE; ABUSE; AMPHETAMINE; OXYTOCIN; INVITRO;
Keywords:
CORTICAL AND HIPPOCAMPAL EEG; INTRACAVERNOUS PRESSURE; POWER SPECTRAL ANALYSIS; ROOT MEAN SQUARE; MEAN POWER FREQUENCY; XYLOCAINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A.Y.W. Chang et al., "DIFFERENTIAL PARTICIPATION OF HIPPOCAMPAL-FORMATION IN COCAINE-INDUCED CORTICAL ELECTROENCEPHALOGRAPHIC DESYNCHRONIZATION AND PENILE ERECTION IN THE RAT", Synapse, 30(2), 1998, pp. 140-149

Abstract

We evaluated the role of the hippocampal formation in cocaine-inducedcortical electroencephalographic (EEG) desynchronization and penile erection. Adult, male Sprague-Dawley rats anesthetized and maintained by chloral hydrate were used. Intravenous (1.5 or 3.0 mg/kg) administration of cocaine dose-dependently increased intracavernous pressure (ICP), our experimental index for penile erection. This was accompanied by desynchronization of EEG activity recorded from the somatosensory cortex (cEEG), as represented by a decrease in root mean square (RMS) and an increase in mean power frequency (MPF) values. There was a simultaneous increase in the RMS values, without significant changes in the MPF values of EEG signals recorded from the hippocampal formation (hEEG). In animals that received prior application of 10% xylocaine eitherintrathecally (i.t.) at the L6-S1 spinal levels or directly into the bilateral hippocampal formation, the RMS values of both cEEG and hEEG signals induced by cocaine (1.5 or 3.0 mg/kg, i.v.) were appreciably reduced, along with a further increase in ICP. Unilateral microinjection of cocaine (15 or 30 mu g) into the hippocampal formation elicited discernible excitation of both cEEG and hEEG signals. Intriguingly, theICP underwent a significant and dose-dependent reduction, which was discernibly antagonized by i.t. application of xylocaine. We conclude that cocaine may effect cortical EEG desynchronizatian but cause a reduction in ICP via an action on the hippocampal formation. Synapse 30:140-149, 1998. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 08/08/20 alle ore 08:54:25