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Titolo:
HUMORAL RESPONSE IN PATIENTS WITH CHRONIC HEART-FAILURE
Autore:
SPINAROVA L; TOMAN J; POSPISILOVA J; SOUCEK M; KARA M; STEJFA M;
Indirizzi:
MASARYK UNIV,DEPT INTERNAL 1,PEKARSKA 53 65 91 BRNO CZECH REPUBLIC MASARYK UNIV,CTR BIOCHEM & NUCL METHODS BRNO CZECH REPUBLIC
Titolo Testata:
International journal of cardiology
fascicolo: 3, volume: 65, anno: 1998,
pagine: 227 - 232
SICI:
0167-5273(1998)65:3<227:HRIPWC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PLASMA ENDOTHELIN;
Keywords:
CHRONIC HEART FAILURE; CYTOKINES; ECHOCARDIOGRAPHY; RIGHT HEART CATHETERIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
L. Spinarova et al., "HUMORAL RESPONSE IN PATIENTS WITH CHRONIC HEART-FAILURE", International journal of cardiology, 65(3), 1998, pp. 227-232

Abstract

Aim: Correlation of five humoral markers with laboratory, echocardiographic and right heart catheterization parameters in patients with chronic heart failure. Study population: 29 patients, heart failure NYHA II, and III, ejection fraction below 40% with coronary artery disease or dilated cardiomyopathy. Methods: evaluation of thromboxane, prostaglandin F (PGF), tumor necrosis factor (TNF) alpha, endothelin-1 and big endothelin rest levels and their correlation with: (1) laboratory parameters: Sodium, urea, creatinine, fibrinogen, (2) chest X-ray: cardiothoracic index (CTI), pulmonary congestion, (3) right heart catheterization parameters at rest, hand-grip and bicycle ergometry: mean pulmonary artery pressure (AP), wedge pressure (WP), systemic and pulmonaryvascular resistance (SVR, PVR) and cardiac index (CI), (4) echocardiographic parameters at rest, hand-grip and bicycle ergometry: end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), mitral flow E/A, filling period of left ventricle and time of durationof mitral regurgitation. Results: No correlation was found between thromboxane, prostaglandin F and tumor necrosis factor alpha with the above mentioned parameters. Endothelin-1 level correlated with E/A, PVR and MPA at rest and at hand-grip. Big endothelin level correlated withEDV and ESV, AP, WP and SVR at rest and at both types of exercise. The highest correlation was between big endothelin and rest AP (r=0.79),rest WP (r=0.78) and CTI (r=0.58), all P<0.01. Conclusions: Big endothelin and partly endothelin-1 levels showed a close correlation with some parameters used for the evaluation of chronic heart failure severity. (C) 1998 Elsevier Science ireland Ltd.

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Documento generato il 25/11/20 alle ore 14:24:33