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Titolo:
TRANSLATIONAL CONTROL OF MHC CLASS-II I-A MOLECULES BY IFN-GAMMA
Autore:
GONALONS E; BARRACHINA M; GARCIASANZ JA; CELADA A;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT FISIOL IMMUNOL,AV DIAGONAL 645 E-08028 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT FISIOL IMMUNOL E-08028 BARCELONA SPAIN UNIV BARCELONA,FDN AUGUST PI I SUNYER E-08028 BARCELONA SPAIN BASEL INST IMMUNOL BASEL SWITZERLAND CSIC,CTR NACL BIOTECNOL,DEPT IMMUNOL & ONCOL MADRID SPAIN
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 4, volume: 161, anno: 1998,
pagine: 1837 - 1843
SICI:
0022-1767(1998)161:4<1837:TCOMCI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MACROPHAGE CELL-LINE; MESSENGER-RNA; HISTOCOMPATIBILITY COMPLEX; SIGNALING PATHWAY; GENE-EXPRESSION; INTERFERON; RECEPTOR; H-2-ANTIGENS; ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E. Gonalons et al., "TRANSLATIONAL CONTROL OF MHC CLASS-II I-A MOLECULES BY IFN-GAMMA", The Journal of immunology (1950), 161(4), 1998, pp. 1837-1843

Abstract

MHC class II molecules are expressed in a limited number of cell types, including B lymphocytes and macrophages (M phi). IFN-gamma increases the surface expression of class II molecules in a murine B cell linewithout inducing detectable changes in either I-A or I-A mRNA levels. In bone marrow-derived M phi, IFN-gamma causes an increase in class II expression at both the mRNA and surface levels, In addition to the increase in transcription rates described for M phi, IFN-gamma increases the rate of synthesis of IA alpha and IA beta proteins and the ribosome loading for both mRNA molecules in both cell types. Interestingly,there is a significant peak of free I-A mRNA in noninduced cells, Therefore, IFN-gamma regulates the expression of MHC class II molecules at the translational level in both B cells and M phi and, as already reported, at the transcriptional level only in M phi. The actual mechanism of regulation causes changes in the translation initiation rates inboth cell types, as demonstrated by an increase in ribosome loading in polysome gradients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:32:40