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Titolo:
DIHYDROPYRIDINE TYPE CALCIUM-CHANNEL BLOCKER-INDUCED TURBID DIALYSATEIN PATIENTS UNDERGOING PERITONEAL-DIALYSIS
Autore:
YOSHIMOTO K; SAIMA S; NAKAMURA Y; NAKAYAMA M; KUBO H; KAWAGUCHI Y; NISHITANI H; NAKAMURA Y; YASUI A; YOKOYAMA K; KURIYAMA S; SHIRAI D; KUGIYAMA A; HAYANO K; FUKUI H; HORIGOME I; AMAGASAKI Y; TSUBAKIHARA Y; KAMEKAWA T; ANDO R; TOMURA S; OKAMOTO R; MIWA S; KOYAMA T; IZUKA T; HONDA Y; ECHIZEN H;
Indirizzi:
MEIJI COLL PHARM,DEPT PHARMACOTHERAPY,1-22-1 YATO CHO TOKYO 188 JAPAN MEIJI COLL PHARM,DEPT PHARMACOTHERAPY TOKYO 188 JAPAN INT MED CTR JAPAN TOKYO JAPAN JIKEI UNIV,SCH MED TOKYO JAPAN SHIRASAGI HOSP TOKYO JAPAN MATSUSHITA MEM HOSP MORIGUCHI OSAKA JAPAN TORANOMON GEN HOSP TOKYO JAPAN OSAKA KOSEI NENKIN HOSP OSAKA JAPAN KUMAMOTO CITY HOSP KUMAMOTO JAPAN SENDAI SHAKAIHOKEN HOSP SENDAI MIYAGI JAPAN SAISEIKAI YOKOHAMA CITY NANBU HOSP YOKOHAMA KANAGAWA JAPAN OSAKA PREFECTURE HOSP OSAKA JAPAN UNIV TSUKUBA TSUKUBA IBARAKI 305 JAPAN AOYAMA HOSP TOKYO JAPAN
Titolo Testata:
Clinical nephrology
fascicolo: 2, volume: 50, anno: 1998,
pagine: 90 - 93
SICI:
0301-0430(1998)50:2<90:DTCBTD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHYLOUS ASCITES;
Keywords:
TURBID PERITONEAL DIALYSATE; CHYLOPERITONEUM; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD); DIHYDROPYRIDINE TYPE CALCIUM CHANNEL BLOCKER; ADVERSE DRUG REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
K. Yoshimoto et al., "DIHYDROPYRIDINE TYPE CALCIUM-CHANNEL BLOCKER-INDUCED TURBID DIALYSATEIN PATIENTS UNDERGOING PERITONEAL-DIALYSIS", Clinical nephrology, 50(2), 1998, pp. 90-93

Abstract

We previously reported that manidipine, a new dihydropyridine type calcium channel blocker, produced chylous peritoneal dialysate being visually indistinguishable from infective peritonitis in 5 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) [Yoshimoto et al. 1993]. To study whether such an adverse drug reaction would also beelicited by other commonly prescribed calcium channel blockers in CARD patients, we have conducted postal inquiry to 15 collaborating hospitals and an institutional survey in International Medical Center of Japan as to the possible occurrence of calcium channel blocker-associated non-infective, turbid peritoneal dialysate in CAPD patients. Our diagnostic criteria for drug-induced turbidity of dialysate as a) it developed within 48 h after the administration of a newly introduced calcium channel blocker to the therapeutic regimen, b) absence of clinical symptoms of peritoneal inflammation (i. e., pyrexia, abdominal pain, nausea or vomiting), c) the fluid containing normal leukocyte counts and being negative for bacterial and fungal culture of the fluid, and d)it disappeared shortly after the withdrawal of the assumed causative agent. Results showed that 19 out of 251 CAPD patients given one of the calcium channel blockers developed non-infective turbid peritoneal dialysis that fulfilled all the above criteria. Four calcium channel blockers were suspected to be associated with the events: benidipine [2 out of 2 (100%) patients given the drug], manidipine [15 out of 36 (42%) patients], nisoldipine [1 out of 11 (9%) patients] and nifedipine [1 out of 159 (0.6%)] in descending order of frequency. None of the patients who received nicardipine, nilvadipine, nitrendipine, barnidipineand diltiazem (25, 7, 2, 1 and 8 patients, respectively) exhibited turbid dialysate. In conclusion, we consider that certain dihydropyridine type calcium channel blockers would cause turbid peritoneal dialysate being similar to that observed in patients developing infective peritonitis. To avoid unnecessary antibiotic therapy the possibility of this adverse reaction should be ruled out whenever a CAPD patient receiving a dihydropyridine type calcium channel blocker develops turbid dialysate.

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Documento generato il 02/04/20 alle ore 11:21:28