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Titolo:
CEREBELLAR MUTISM SYNDROME
Autore:
JANSSEN G; MESSINGJUNGER AM; ENGELBRECHT V; GOBEL U; BOCK WJ; LENARD HG;
Indirizzi:
UNIV DUSSELDORF,KINDERKLIN,KLIN HAMATOL & ONKOL,MOORENSTR 5 D-40225 DUSSELDORF GERMANY UNIV DUSSELDORF,CHILDRENS HOSP D-4000 DUSSELDORF GERMANY UNIV DUSSELDORF,DEPT NEUROSURG D-4000 DUSSELDORF GERMANY UNIV DUSSELDORF,DEPT DIAGNOST RADIOL D-4000 DUSSELDORF GERMANY
Titolo Testata:
Klinische Padiatrie
fascicolo: 4, volume: 210, anno: 1998,
pagine: 243 - 247
SICI:
0300-8630(1998)210:4<243:>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOSSA SURGERY; CHILDREN; PATHOPHYSIOLOGY; RESECTION; MUTENESS; ORIGIN;
Keywords:
CEREBELLAR MUTISM; CEREBELLAR TUMOR; POSTERIOR FOSSA SYNDROME; POSTERIOR FOSSA TUMOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
G. Janssen et al., "CEREBELLAR MUTISM SYNDROME", Klinische Padiatrie, 210(4), 1998, pp. 243-247

Abstract

Since 1980, a growing number of pediatric patients with mutism following posterior fossa surgery have been recognized. This syndrome typically affects children and in rare cases young adults who become mute one or two days after tumor operation but do not show disturbances of consciousness or language comprehension. The disorder persists for 1 to 4 months. The pathogenesis is still unknown. Of 21 children who underwent surgery for large posterior fossa tumors between 1991 and 1995, 6 developed cerebellar mutism. Histologically the tumors were classifiedas astrocytoma WHO grade I, astrocytoma WHO grade II and ependymoma WHO grade III in one case and medulloblastoma WHO grade IV in three cases.Besides the clinical course, intraoperative findings and CT or MRI data are evaluated and discussed considering possible etiological hypotheses. Our own experience and also literature reviews suggest that the lesion of the cerebellar hemispheres might be the most important oneof multiple factors causing cerebellar mutism. Generally the syndromeis transient. The diagnosis should not delay adjuvant therapy in patients with a malignancy.

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Documento generato il 13/07/20 alle ore 17:10:11