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Titolo:
MONITORING TUMOR-ACTIVITY IN LOW-GRADE GLIOMA OF CHILDHOOD
Autore:
MOLENKAMP G; RIEMANN B; KUWERT T; STRATER R; KURLEMANN G; SCHOBER O; JURGENS H; WOLFF JEA;
Indirizzi:
UNIV MUNSTER,CHILDRENS HOSP,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT PEDIAT ONCOL D-4400 MUNSTER GERMANY UNIV MUNSTER,DEPT NUCL MED D-4400 MUNSTER GERMANY UNIV MUNSTER,DEPT PEDIAT NEUROL D-4400 MUNSTER GERMANY ALBERTA CHILDRENS PROV GEN HOSP,DEPT PEDIAT ONCOL CALGARY AB T2T 5C7 CANADA
Titolo Testata:
Klinische Padiatrie
fascicolo: 4, volume: 210, anno: 1998,
pagine: 239 - 242
SICI:
0300-8630(1998)210:4<239:MTILGO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALPHA-METHYL TYROSINE; BRAIN-TUMORS; COMPUTED-TOMOGRAPHY; FDG-PET; DIFFERENTIATION; PERFORMANCE; CHILDREN;
Keywords:
LOW GRADE GLIOMA; NEURORADIOLOGY; IODINE-123-ALPHA-METHYLTHYROSINE SPECT; F-18 FLUORODESOXYGLUCOSE PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G. Molenkamp et al., "MONITORING TUMOR-ACTIVITY IN LOW-GRADE GLIOMA OF CHILDHOOD", Klinische Padiatrie, 210(4), 1998, pp. 239-242

Abstract

Chemotherapeutic or radiotherapeutic regimens are being increasingly used in low grade glioma of childhood. These protocols require methodsto monitor tumor activity. We report our experience in eleven patients. The tumors were localized in the optic pathway (3), cerebral cortex(4) and thalamus/hypothalamus (4). Histological diagnoses included low grade astrocytoma (6), gliofibroma (1) and ganglioglioma (2). Two children with neurofibromatosis type 1 (NF-1) and typical optical tumorswere not biopsied. 13 episodes of progression were noted including 3 altered diagnoses. This was evident from clinical symptoms in 11/13 episodes, computed tomography (CT) or magnetic resonance imaging (MRI) in 10/13 situations, iodine-123-alpha-methyltyrosine (I-123-IMT) single-photon emission computed tomography (SPECT) in 10/10 situations, fluorine-18 fluorodesoxyglucose (F-18-FDG) positron emission tomography (PET) in 0/3 and thallium-201 (Tl-201) SPECT in 1/1. Seven responses to chemotherapy were recorded. Clinical symptoms indicated this in 7/7 situations, MRI in 5/7, I-123-IMT SPECT in 1/2 and Tl-201 SPECT in 1/1. These data suggest that I-123-LMT SPECT is a valuable addition to low grade glioma diagnostic and stress the need for a prospective study.

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Documento generato il 17/01/21 alle ore 08:06:04