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Titolo:
MYELODYSPLASTIC SYNDROME WITH B-CELL CLONALITY IN A PATIENT 5 YEARS AFTER RENAL-TRANSPLANTATION
Autore:
OKAMOTO T; OKADA M; ITOH T; MORI A; SAHEKI K; TAKATSUKA H; WADA H; TAMURA A; FUJIMORI Y; TAKEMOTO Y; KANAMARU A; KAKISHITA E;
Indirizzi:
HYOGO MED UNIV,DEPT INTERNAL MED 2,1-1 MUKOGAWA CHO NISHINOMIYA HYOGO663 JAPAN
Titolo Testata:
International journal of hematology
fascicolo: 1, volume: 68, anno: 1998,
pagine: 61 - 65
SICI:
0925-5710(1998)68:1<61:MSWBCI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINEAGE INVOLVEMENT; PERIPHERAL-BLOOD; GENE; POLYMORPHISMS; HYBRIDIZATION; GRANULOCYTES; METHYLATION; ANEMIA; REPEAT;
Keywords:
RENAL TRANSPLANTATION; MYELODYSPLASTIC SYNDROME; B LYMPHOCYTE; TRISOMY 8; CLONALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
T. Okamoto et al., "MYELODYSPLASTIC SYNDROME WITH B-CELL CLONALITY IN A PATIENT 5 YEARS AFTER RENAL-TRANSPLANTATION", International journal of hematology, 68(1), 1998, pp. 61-65

Abstract

A female patient received a renal transplantation from an unrelated cadaver donor, and five years later developed myelodysplastic syndrome (MDS) with immunological abnormalities. Chromosomal analysis showed trisomy 8 in bone marrow cells. FISH analysis indicated that trisomy 8 was present in 4% of CD19+ cells, suggesting that the MDS clone involved B lymphocytes. Polymerase chain reaction of the human androgen receptor gene indicated B cell clonality (54%) and granulocyte clonality (63%). There have been no previous reports of secondary MDS following renal transplantation in which the MDS clone involved the B cell lineage. The abnormal MDS B cell clone may have caused the immunological abnormalities. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:21:12