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Titolo:
AGGRESSION, IMPULSIVITY, AND CENTRAL-NERVOUS-SYSTEM SEROTONERGIC RESPONSIVITY IN A NONPATIENT SAMPLE
Autore:
MANUCK SB; FLORY JD; MCCAFFERY JM; MATTHEWS KA; MANN JJ; MULDOON MF;
Indirizzi:
UNIV PITTSBURGH,BEHAV PHYSIOL LAB,DEPT PSYCHOL,506 EH,4015 OHARA ST PITTSBURGH PA 15260 UNIV PITTSBURGH,SCH MED,DEPT PSYCHIAT PITTSBURGH PA 15260 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT NEUROSCI NEW YORK NY 10032
Titolo Testata:
Neuropsychopharmacology
fascicolo: 4, volume: 19, anno: 1998,
pagine: 287 - 299
SICI:
0893-133X(1998)19:4<287:AIACSR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; DISRUPTIVE BEHAVIOR DISORDERS; III PERSONALITY-DISORDERS; MALE CYNOMOLGUS MACAQUES; RANGING RHESUS-MONKEYS; CHRONIC SOCIAL STRESS; D-FENFLURAMINE; 5-HYDROXYINDOLEACETIC ACID; CSF 5-HIAA; PROLACTIN SECRETION;
Keywords:
SEROTONIN; AGGRESSION; IMPULSIVITY; FENFLURAMINE CHALLENGE; PROLACTIN; MONOAMINES; TEMPERAMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Manuck et al., "AGGRESSION, IMPULSIVITY, AND CENTRAL-NERVOUS-SYSTEM SEROTONERGIC RESPONSIVITY IN A NONPATIENT SAMPLE", Neuropsychopharmacology, 19(4), 1998, pp. 287-299

Abstract

To test the hypothesis that traits of aggression and impulsivity correlate negatively with central serotonergic system function in a nonpatient population, a standard fenfluramine challenge (for assessment of serotonergic responsivity) and behavioral measurements germane to aggression/impulsivity were administered to a community-derived sample of 119 men and women. In men, peak prolactin responses to fenfluramine correlated significantly with an interview-assessed life history of aggression (r = -.40, p < .002), the Barratt Impulsiveness Scale (r = -.30, p < .03), and traits of Conscientiousness (r = +.30, p < .03), Neuroticism (r = -.31, p < .02) and Angry Hostility (r = -.35, p < .01)on the NEO-Personality Inventory. No significant relationships were observed across all women, although subanalyses restricted to postmenopausalsubjects (in whom ovarian influences on prolactin secretion may be mitigated because of diminished estrogen) showed a pattern of behavioralassociations somewhat similar to that seen in men. By extending documented relationships between an index of central serotonergic system function and traits of aggression and impulsivity to a more normative range of population variability than is represented in prior literature,this study supports speculation that these associations reflect a basic neurobehavioral dimension of individual differences. (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 10/07/20 alle ore 15:56:22