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Titolo:
RECREATIONAL USE OF ECSTASY (MDMA) IS ASSOCIATED WITH ELEVATED IMPULSIVITY
Autore:
MORGAN MJ;
Indirizzi:
UNIV COLL SWANSEA,DEPT PSYCHOL,CTR SUBST ABUSE RES,SINGLETON PK SWANSEA SA2 8PP W GLAM WALES
Titolo Testata:
Neuropsychopharmacology
fascicolo: 4, volume: 19, anno: 1998,
pagine: 252 - 264
SICI:
0893-133X(1998)19:4<252:RUOE(I>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; TRYPTOPHAN DEPLETION; NORMAL MALES; SEROTONIN; HUMANS; MOOD; NEUROTOXICITY; PHARMACOLOGY;
Keywords:
MDMA; SEROTONIN; NEUROTOXICITY; IMPULSIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Morgan, "RECREATIONAL USE OF ECSTASY (MDMA) IS ASSOCIATED WITH ELEVATED IMPULSIVITY", Neuropsychopharmacology, 19(4), 1998, pp. 252-264

Abstract

Recent preclinical evidence suggests that repeated exposure to 3, 4-methylenedioxy-methamphetamine (MDMA; ''ecstasy'') produces long-term reductions in serotonin (5-HT) levels. 5-HT has been implicated in the regulation of mood, anxiety, aggression, impulsivity, and cognition. Accordingly, in the first of two separate studies, these variables wereinvestigated irt three groups: (1) MDMA group-recreational ecstasy users (who also used other illicit substances); (2) polydrug controls-who had never taken Ecstasy, bur otherwise had drug histories and personal characteristics similar to the ecstasy users; and (3) nondrug controls-who had never used illicit drugs, but had similar personal characteristics. All participants completed mood (Likert) scales, personalityquestionnaires (which included the impulsiveness, venturesomeness andempathy questionnaire-IVE), spatial span and ''Tower of London'' (TOL) tests, and a behavioral measure of impulsivity, the matching familiar figures test (MFF20). There were no group differences in mood, anxiety, anger/hostility, and cognitive performance, but the MDMA group committed significantly more errors in the MFF20. Subsequently, a larger sample of participants were administered mood (the General Health Questionnaire or GHQ) and personality (IVE) questionnaires before the administration of a TOL test, followed by the MFF20, and a second TOL rest. Although there were no group differences in TOL performance, ecstasyusers were again found to commit more errors in the MFF20 than polydrug users. Furthermore, the GHQ and IVE scores of the ecstasy users in the second study indicated, respectively, that they were more psychologically disturbed and impulsive than nondrug controls. The combined data from the two studies indicated that ecstasy users exhibited elevated impulsivity on both self-report and behavioral measures and that those who had taken the most ecstasy had the most elevated trait impulsiveless scores. These findings are consistent with previous evidence that elevated levels of impulsivity in humans are associated with reducedlevels of serotonergic function. (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 31/03/20 alle ore 19:22:53