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Titolo:
PSYCHOLOGICAL AND CARDIOVASCULAR EFFECTS AND SHORT-TERM SEQUELAE OF MDMA (ECSTASY) IN MDMA-NAIVE HEALTHY-VOLUNTEERS
Autore:
VOLLENWEIDER FX; GAMMA AG; LIECHTI M; HUBER T;
Indirizzi:
PSYCHIAT UNIV HOSP,DEPT RES,POB 68 CH-8029 ZURICH SWITZERLAND PSYCHIAT UNIV HOSP,DEPT INNER MED CH-8029 ZURICH SWITZERLAND
Titolo Testata:
Neuropsychopharmacology
fascicolo: 4, volume: 19, anno: 1998,
pagine: 241 - 251
SICI:
0893-133X(1998)19:4<241:PACEAS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; RECREATIONAL USERS; PANIC DISORDER; NEUROTOXICITY; ENTACTOGENS; NEURONS; DRUGS; MDE;
Keywords:
MDMA (3,4-METHYLENEDIOXYMETHAMPHETAMINE ECSTASY); SEROTONIN; PSYCHOLOGICAL EFFECTS; STROOP COLORNAMING TEST; CARDIOVASCULAR EFFECTS; BODY TEMPERATURE; ADVERSE EFFECTS; ENTACTOGEN; HALLUCINOGEN; STIMULANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
F.X. Vollenweider et al., "PSYCHOLOGICAL AND CARDIOVASCULAR EFFECTS AND SHORT-TERM SEQUELAE OF MDMA (ECSTASY) IN MDMA-NAIVE HEALTHY-VOLUNTEERS", Neuropsychopharmacology, 19(4), 1998, pp. 241-251

Abstract

3,4-methylenedioxymethamphetamine (MDMA, ''Ecstasy'') is a recreational drug reported to produce a different psychological profile than that of classic hallucinogens and stimulants. It has, therefore, been tentatively classified into a novel pharmacological class termed entactogens. This double-blind placebo-controlled study examined the effects of a typical recreational dose of MDMA (1.7 mg/kg) in 13 MDMA-naive healthy volunteers. MDMA produced an affective state of enhanced mood, well-being, and increased emotional sensitiveness, little anxiety, but no hallucinations or panic reactions. Mild depersonalization and derealization phenomena occurred together with moderate thought disorder,first signs of loss gf body control, and alterations in the meaning of percepts. Subjects also displayed changes in the sense of space and time, heightened sensory awareness, and increased psychomotor drive. MDMA did not impair selective attention Its measured by the Stroop test. MDMA increased blood pressure moderately, with the exception of one subject who showed a transient hypertensive reaction. This severe increasein blood pressure indicates that the hypertensive effects of MDMA, even at recreational doses, should not be underestimated, particularly in subjects with latent cardiovascular problems. Most frequent acute somatic complaints during the MDMA challenge were jaw clenching, lack ofappetite, impaired gait, and restless legs. Adverse sequelae during the following 24 hours included lack of energy and appetite, feelings of restlessness, insomnia, jaw clenching, occasional difficulty concentrating, and brooding. The present findings are consistent with the hypothesis that MDMA produces a different psychological profile than classic hallucinogens or psychostimulants. (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 02/04/20 alle ore 12:58:45