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Titolo:
HYPOFIBRINOGENEMIA IN NON-M3 ACUTE MYELOID-LEUKEMIA - INCIDENCE, CLINICAL AND LABORATORY CHARACTERISTICS AND PROGNOSIS
Autore:
WELTERMANN A; PABINGER I; GEISSLER K; JAGER U; GISSLINGER H; KNOBL P; EICHINGER S; KYRLE PA; VALENT P; SPEISER W; SCHWARZINGER I; MANNHALTER C; LECHNER K;
Indirizzi:
ALLGEMEINES KRANKENHAUS WIEN,DEPT INTERNAL MED 1,DIV HEMATOL & HEMOSTASEOL A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT MED 1,DIV HEMATOL & HEMOSTASEOL A-1010 VIENNA AUSTRIA UNIV VIENNA,CLIN INST MED & CHEM LAB MED A-1010 VIENNA AUSTRIA
Titolo Testata:
Leukemia
fascicolo: 8, volume: 12, anno: 1998,
pagine: 1182 - 1186
SICI:
0887-6924(1998)12:8<1182:HINAM->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISSEMINATED INTRAVASCULAR COAGULATION; ACUTE PROMYELOCYTIC LEUKEMIA; BLEEDING COMPLICATIONS; APL;
Keywords:
ACUTE LEUKEMIA; HYPOFIBRINOGENEMIA; COAGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Weltermann et al., "HYPOFIBRINOGENEMIA IN NON-M3 ACUTE MYELOID-LEUKEMIA - INCIDENCE, CLINICAL AND LABORATORY CHARACTERISTICS AND PROGNOSIS", Leukemia, 12(8), 1998, pp. 1182-1186

Abstract

Among 379 patients with AML with FAB type MI, 2 and M4-7 diagnosed between 1978 and 1997 in our institution, 19 (5%) had hypofibrinogenemia(HF), ie a fibrinogen level < 180 mg/dl. Compared to patients with normal fibrinogen (n = 360) patients with HF had significantly elevated markers of activation of coagulation (TAT, F1.2, FPA) and fibrinolysis(D-dimer, FDP) indicating that disseminated intravascular coagulation/hyperfibrinolysis was the cause of hypofibrinogenemia. Patients with HF had significantly longer prothrombin times, thrombin clotting and reptilase times. Factor X and VIII were significantly lower than in patients without HF. With the exception of M7, HF occurred in all FAB subtypes, but was most common in M5 (12.1%). Patients with HF did not differ from those with normal fibrinogen with regard to age, sex, leukocyte count and other hematological parameters. During induction chemotherapy fibrinogen normalized rapidly (median 5 days) and there was no increased incidence of early hemorrhagic death. The overall and disease-free survival was similar to that of patients without HF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 01:59:52