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Titolo:
ANTIVIRAL CHEMOTHERAPY - MECHANISM OF ACT ION, ACTIVITY EVALUATION, RESISTANCE AND FURTHER DEVELOPMENTS
Autore:
AGUT H; FILLET AM; HURAUX JM;
Indirizzi:
CERVI,BACTERIOL VIROL LAB,HOSP PITIE SALPETRIERE GRP,83 BLVD HOP F-75651 PARIS 13 FRANCE
Titolo Testata:
Pathologie et biologie
fascicolo: 8BIS, volume: 41, anno: 1993,
pagine: 770 - 776
SICI:
0369-8114(1993)41:8BIS<770:AC-MOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
FRE
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HERPES-SIMPLEX; REVERSE-TRANSCRIPTASE; REPLICATION INVITRO; SENSITIVITY; ZIDOVUDINE; GANCICLOVIR; ACYCLOVIR; INHIBITION; FOSCARNET;
Keywords:
ADN POLYMERASE; THYMIDINE KINASE; ACYCLOVIR; ZIDOVUDINE; IN-VITRO RESISTANCE; SENSITIVITY TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H. Agut et al., "ANTIVIRAL CHEMOTHERAPY - MECHANISM OF ACT ION, ACTIVITY EVALUATION, RESISTANCE AND FURTHER DEVELOPMENTS", Pathologie et biologie, 41(8BIS), 1993, pp. 770-776

Abstract

Antiviral chemotherapy is based on the selective inhibition of intracellular virus multiplication. Inhibitors of viral DNA polymerases perfectly exemplifies this mode of action. In spite of their selectivity, some of these drugs are cytotoxic and all remain unefficient against latent viruses. Evaluation of antiviral activity requires in vitro sensitivity tests, in vivo studies on animals and virological analyses during clinical trials. This evaluation needs well standardized assays. The emergence of in vitro resistance reflects the occurrence of mutations regarding target enzymes. Clinical significance of antiviral drug resistance needs to be assessed in many circumstances, even if its association with immunodeficiency often leads to a clear therapeutic failure. Further developments will include the synthesis of novel inhibitors, study of drug associations and improvement of virological diagnosistechniques relevant to therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:19:14