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Titolo:
EXPRESSION AND FUNCTION OF THE MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR-RECEPTOR IN ACUTE MYELOID-LEUKEMIA BLASTS
Autore:
WETZLER M; BERNSTEIN SH; BAUMANN H; FRIES KM; STEWART C; BLUMENSON L; BAER MR; HERZIG GP; BLOOMFIELD CD; SLACK JL;
Indirizzi:
ROSWELL PK CANC INST,DEPT HEMATOL ONCOL,DIV MED BUFFALO NY 14263
Titolo Testata:
Leukemia & lymphoma
fascicolo: 5-6, volume: 30, anno: 1998,
pagine: 415 -
SICI:
1042-8194(1998)30:5-6<415:EAFOTM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOBLASTIC-LEUKEMIA; ACUTE MYELOCYTIC-LEUKEMIA; RECOMBINANT HUMAN THROMBOPOIETIN; STIMULATING FACTOR RECEPTORS; ACUTE MYELOGENOUS LEUKEMIA; STEM-CELL TRANSPLANTATION; C-MPL LIGAND; INDUCED THROMBOCYTOPENIA; FLOW-CYTOMETRY; MESSENGER-RNA;
Keywords:
FUNCTION; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; MGDF; MGDF RECEPTOR; AML; ACUTE MYELOID LEUKEMIA BLASTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
M. Wetzler et al., "EXPRESSION AND FUNCTION OF THE MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR-RECEPTOR IN ACUTE MYELOID-LEUKEMIA BLASTS", Leukemia & lymphoma, 30(5-6), 1998, pp. 415

Abstract

The receptor for megakaryocyte growth and development factor (MGDF), also known as thrombopoietin, has recently been cloned. MGDF stimulates platelet production and maturation both in vitro and in vivo. MGDF may thus have a role in attenuating the thrombocytopenia associated with acute myeloid leukemia (AML) and its therapy. However, there is concern that MGDF might induce AML blast proliferation and thereby increase the risk of treatment failure. To address this concern, we studied the expression of c-mpl mRNA and c-Mpl protein by blasts from AML patients. In addition we examined the in vitro effect of MGDF as well as the combined effect of MGDF and granulocyte colony-stimulating factor (G-CSF) or stem cell factor (SCF) on leukemic blast proliferation, recruitment into S-phase, induction of programmed cell death and activationof signal transducers and activators of transcription (STAT) proteins. Our results demonstrate that blasts from a substantial proportion ofcases of AML express the receptor at either the mRNA or protein level. Moreover, the function of the MGDF receptor was demonstrated by activation of STAT proteins following exposure to MGDF. Nevertheless, blast proliferation in response to MGDF was rare, and the proliferative effect of MGDF was less than that of G-CSF or SCF. Furthermore, MGDF didnot prevent programmed cell death induced by cytarabine. Finally, there appeared to be no correlation between receptor expression by AML blasts and functional response to MGDF. Based on these data, it would appear that clinical trials of MGDF may be undertaken safely in patientswith AML.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 20:17:21