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Titolo:
MOLECULAR EVOLUTION OF A DUPLICATION - THE SEX-PEPTIDE (ACP70A) GENE REGION OF DROSOPHILA-SUBOBSCURA AND DROSOPHILA-MADEIRENSIS
Autore:
CIRERA S; AGUADE M;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT GENET,DIAGONAL 645 E-08071 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT GENET E-08071 BARCELONA SPAIN
Titolo Testata:
Molecular biology and evolution
fascicolo: 8, volume: 15, anno: 1998,
pagine: 988 - 996
SICI:
0737-4038(1998)15:8<988:MEOAD->2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE SELECTION; REPRODUCTIVE-BEHAVIOR; DNA-SEQUENCE; RP49 REGION; MELANOGASTER; POLYMORPHISM; SOFTWARE; PROTEIN; SUBSTITUTION; ARRANGEMENTS;
Keywords:
POLYMORPHISM; DIVERGENCE; DUPLICATION; ADAPTIVE EVOLUTION; DROSOPHILA; SEX-PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
S. Cirera e M. Aguade, "MOLECULAR EVOLUTION OF A DUPLICATION - THE SEX-PEPTIDE (ACP70A) GENE REGION OF DROSOPHILA-SUBOBSCURA AND DROSOPHILA-MADEIRENSIS", Molecular biology and evolution, 15(8), 1998, pp. 988-996

Abstract

In Drosophila melanogaster; the Acp70A gene, which is involved in thepostmating reactions of the female, is a single-copy gene. However, in Drosophila subobscura, the gene is duplicated and both copies are transcribed. To study the molecular evolution of the duplication, a 2.1-kb fragment encompassing both copies of the duplication was sequenced for 10 lines of D, subobscura and one line of Drosophila madeirensis. Estimates of the divergence between the two copies of the duplicated region and between the two species studied, D. subobscura and D. madeirensis, revealed that both copies of the Acp70A gene had evolved independently since their duplication. The ratio of nonsynonymous to silent divergence between copies was generally higher than one. The McDonald and Kreitman test revealed an excess of nonsynonymous changes fixed since the duplication and before the split of the D. subobscura and D. madeirensis lineages. These results point to natural selection driving protein evolution after the duplication. Specifically, adaptive evolution appears to have caused the initial differentiation between copies of the N-terminal parts: of the proteins, while purifying selection could be responsible for the high conservation of the C-terminal parts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:02:34